(5S)-1-(3-methoxybenzyl)-5-(hydroxymethyl)-2-pyrrolidin-2-one tosyl ester

Base Information

Chemical Name:(5S)-1-(3-methoxybenzyl)-5-(hydroxymethyl)-2-pyrrolidin-2-one tosyl ester
CAS No.:871820-02-9
Molecular Formula:C₂₀H₂₃NO₅S
Molecular Weight:389.472
Hs Code.:

Synonyms:(5S)-1-(3-methoxybenzyl)-5-(hydroxymethyl)-2-pyrrolidin-2-one tosyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S)-1-(3-methoxybenzyl)-5-(hydroxymethyl)-2-pyrrolidin-2-one tosyl ester

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Technology Process of (5S)-1-(3-methoxybenzyl)-5-(hydroxymethyl)-2-pyrrolidin-2-one tosyl ester

There total 4 articles about (5S)-1-(3-methoxybenzyl)-5-(hydroxymethyl)-2-pyrrolidin-2-one tosyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 871816-01-2
(5S)-1-(3-methoxybenzyl)-5-(carboxymethyl)-2-pyrrolidin-2-one

: 98-59-9
p-toluenesulfonyl chloride

: 871820-02-9
(5S)-1-(3-methoxybenzyl)-5-(hydroxymethyl)-2-pyrrolidin-2-one tosyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2006.02.044

Reference yield:

: 871815-98-4
(5S)-1-(3-methoxybenzyl)-5-carbomethoxy-2-pyrrolidin-2-one

: 871820-02-9
(5S)-1-(3-methoxybenzyl)-5-(hydroxymethyl)-2-pyrrolidin-2-one tosyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / LiBH₄ / tetrahydrofuran / 0.75 h / 20 °C

2: 65 percent / triethylamine / CH₂Cl₂ / 20 °C

With lithium borohydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2006.02.044

Reference yield:

: 4931-66-2
methyl (S)-pyroglutamate

: 871820-02-9
(5S)-1-(3-methoxybenzyl)-5-(hydroxymethyl)-2-pyrrolidin-2-one tosyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / NaH / tetrahydrofuran / 1 h / 0 - 20 °C

2: 97 percent / LiBH₄ / tetrahydrofuran / 0.75 h / 20 °C

3: 65 percent / triethylamine / CH₂Cl₂ / 20 °C

With lithium borohydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2006.02.044