(2R,1'R)-1-(2-benzyloxymethyl-5-methoxychroman-2-yl)-1,2-(bis-tertbutyldimethylsilyloxy)ethane

Base Information

Chemical Name:(2R,1'R)-1-(2-benzyloxymethyl-5-methoxychroman-2-yl)-1,2-(bis-tertbutyldimethylsilyloxy)ethane
CAS No.:1616779-90-8
Molecular Formula:C₃₃H₅₄O₅Si₂
Molecular Weight:586.96
Hs Code.:

Synonyms:(2R,1'R)-1-(2-benzyloxymethyl-5-methoxychroman-2-yl)-1,2-(bis-tertbutyldimethylsilyloxy)ethane

Suppliers and Price of (2R,1'R)-1-(2-benzyloxymethyl-5-methoxychroman-2-yl)-1,2-(bis-tertbutyldimethylsilyloxy)ethane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2R,1'R)-1-(2-benzyloxymethyl-5-methoxychroman-2-yl)-1,2-(bis-tertbutyldimethylsilyloxy)ethane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,1'R)-1-(2-benzyloxymethyl-5-methoxychroman-2-yl)-1,2-(bis-tertbutyldimethylsilyloxy)ethane

There total 10 articles about (2R,1'R)-1-(2-benzyloxymethyl-5-methoxychroman-2-yl)-1,2-(bis-tertbutyldimethylsilyloxy)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 1616779-88-4
(1’R,2R)-1-(2-benzyloxymethyl-5-methoxy-7-methylchroman-2-yl)ethane-1,2-diol

: 1616779-90-8
(2R,1'R)-1-(2-benzyloxymethyl-5-methoxychroman-2-yl)-1,2-(bis-tertbutyldimethylsilyloxy)ethane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 2.5h;
DOI:10.1002/chem.201402495

Reference yield:

: 1616779-81-7
(E)-1-benzyloxy-4-(2,6-dimethoxy-4-methylphenyl)-but-3-en-2-one

: 1616779-90-8
(2R,1'R)-1-(2-benzyloxymethyl-5-methoxychroman-2-yl)-1,2-(bis-tertbutyldimethylsilyloxy)ethane

Guidance literature:: Multi-step reaction with 8 steps

1.1: platinum(IV) oxide; hydrogen / ethyl acetate / 2.25 h / 20 °C / 760.05 Torr

1.2: 1 h / 80 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C

2.2: 4 h / 0 - 20 °C

3.1: sodium ethanolate / N,N-dimethyl-formamide / 21 h / 120 °C

4.1: (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; palladium(II) trifluoroacetate; p-benzoquinone / methanol / 24 h / 20 °C

5.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C

6.1: ortho-nitrophenyl selenocyanate; tributylphosphine / tetrahydrofuran / 4 h / 0 °C

6.2: 4 h / -40 °C

6.3: 15 h / -40 °C

7.1: potassium osmate(VI) dihydrate; (DHQ)2-AQN; potassium hexacyanoferrate(III); potassium carbonate / tert-butyl alcohol; water / 72 h / 20 °C

8.1: 2,6-dimethylpyridine / dichloromethane / 2.5 h / 0 °C

With 2,6-dimethylpyridine; platinum(IV) oxide; potassium osmate(VI) dihydrate; lithium aluminium tetrahydride; n-butyllithium; ortho-nitrophenyl selenocyanate; palladium(II) trifluoroacetate; tributylphosphine; potassium hexacyanoferrate(III); (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; (DHQ)2-AQN; hydrogen; sodium ethanolate; potassium carbonate; p-benzoquinone; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/chem.201402495

Reference yield:

: 1616779-82-8
1-benzyloxy-4-(2,6-dimethoxy-4-methylphenyl)-butan-2-one

: 1616779-90-8
(2R,1'R)-1-(2-benzyloxymethyl-5-methoxychroman-2-yl)-1,2-(bis-tertbutyldimethylsilyloxy)ethane

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C

1.2: 4 h / 0 - 20 °C

2.1: sodium ethanolate / N,N-dimethyl-formamide / 21 h / 120 °C

3.1: (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; palladium(II) trifluoroacetate; p-benzoquinone / methanol / 24 h / 20 °C

4.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C

5.1: ortho-nitrophenyl selenocyanate; tributylphosphine / tetrahydrofuran / 4 h / 0 °C

5.2: 4 h / -40 °C

5.3: 15 h / -40 °C

6.1: potassium osmate(VI) dihydrate; (DHQ)2-AQN; potassium hexacyanoferrate(III); potassium carbonate / tert-butyl alcohol; water / 72 h / 20 °C

7.1: 2,6-dimethylpyridine / dichloromethane / 2.5 h / 0 °C

With 2,6-dimethylpyridine; potassium osmate(VI) dihydrate; lithium aluminium tetrahydride; n-butyllithium; ortho-nitrophenyl selenocyanate; palladium(II) trifluoroacetate; tributylphosphine; potassium hexacyanoferrate(III); (S)-2,2’-bis-[(4S)-(-iso-butyl)-4,5-dihydrooxazol-2-yl]-1,1’-binaphthalene; (DHQ)2-AQN; sodium ethanolate; potassium carbonate; p-benzoquinone; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/chem.201402495