Nestorone

Base Information

Chemical Name:Nestorone
CAS No.:7759-35-5
Molecular Formula:C₂₃H₃₀O₄
Molecular Weight:370.489
Hs Code.:
European Community (EC) Number:643-056-7
UNII:9AMX4Q13CC
DSSTox Substance ID:DTXSID70998804
Nikkaji Number:J59.374E
Wikipedia:Segesterone_acetate
Wikidata:Q1978481
NCI Thesaurus Code:C152316
RXCUI:2055977
Metabolomics Workbench ID:154975
ChEMBL ID:CHEMBL3707377
Mol file:7759-35-5.mol

Synonyms:16-methylene-17alpha-acetoxy-19-nor-4-pregnen-3,20-dione;Nestorone;ST 1435;ST-1435

Suppliers and Price of Nestorone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SegesteroneAcetate
10mg
$ 130.00

Sigma-Aldrich
Nestorone ≥97% (HPLC)
10mg
$ 80.50

Sigma-Aldrich
Nestorone ≥97% (HPLC)
50mg
$ 311.00

DC Chemicals
Nestorone >98%
25 mg
$ 135.00

DC Chemicals
Nestorone >98%
100 mg
$ 225.00

Crysdot
Nestoron 98+%
50mg
$ 174.00

Crysdot
Nestoron 98+%
10mg
$ 42.00

Cayman Chemical
Segesterone Acetate
10mg
$ 63.00

Cayman Chemical
Segesterone Acetate
5mg
$ 35.00

Cayman Chemical
Segesterone Acetate
25mg
$ 149.00

Total 50 raw suppliers

Chemical Property of Nestorone

Chemical Property:

Vapor Pressure:4.2E-10mmHg at 25°C
Melting Point:178-179°
Refractive Index:1.4433 (estimate)
Boiling Point:499.3°Cat760mmHg
Flash Point:216.2°C
PSA：60.44000
Density:1.15g/cm³
LogP:4.18520
Storage Temp.:2-8°C
Solubility.:DMSO: soluble5mg/mL, clear
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:370.21440943
Heavy Atom Count:27
Complexity:762

Purity/Quality:

99% ^*data from raw suppliers

SegesteroneAcetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1(C(=C)CC2C1(CCC3C2CCC4=CC(=O)CCC34)C)OC(=O)C
Isomeric SMILES:CC(=O)[C@]1(C(=C)C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@H]34)C)OC(=O)C
Recent ClinicalTrials:Study of Daily Application of Nestorone? (NES) and Testosterone (T) Combination Gel for Male Contraception
Recent EU Clinical Trials:A dose-finding randomized clinical trial to evaluate the differential impact of four progestins for their use as male contraceptives in healthy men.
Uses Segesterone Acetate has been used to study the: comparison of androgenic and estrogenic properties of progestins used in contraception and hormone therapy; impact on hepatic estrogen-sensitive proteins by 1-yr contraceptive vaginal ring delivering Nestorone and ethinyl estradiol.
Clinical Use Because of its antiestrogenic action, elcometrine also can be administered transdermally along with estradiol as a treatment for menopausal symptoms .

Technology Process of Nestorone

There total 4 articles about Nestorone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: