C₃₄H₄₁N₅O₆

Base Information

• Chemical Name: C₃₄H₄₁N₅O₆
• CAS No.: 868286-82-2
• Molecular Formula: C₃₄H₄₁N₅O₆
• Molecular Weight: 615.729
• Mol file: 868286-82-2.mol

Synonyms:C₃₄H₄₁N₅O₆

Chemical Property of C₃₄H₄₁N₅O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₄H₄₁N₅O₆

There total 5 articles about C₃₄H₄₁N₅O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{3-[5-((1R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-5-[(dipropylamino)carbonyl]phenyl}-3-furoic acid (868286-75-3) → C34H41N5O6 (868286-82-2)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 5h;

Reference yield:

tert-butyl [1-(5-{3-bromo-5-[(dipropylamino)carbonyl]phenyl}-1,3,4-oxadiazol-2-yl)-(1R)-1-methyl-2-phenylethyl]carbamate (868286-60-6) → C34H41N5O6 (868286-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 18 h / 120 °C

2: lithium hydroxide; water / tetrahydrofuran / 50 h / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 5 h / 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; water; sodium carbonate; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water;

Reference yield:

3-bromo-5-(5-((1R)-1-[(tert-butoxycarbonyl)amino]-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl)benzoic acid (1048686-05-0) → C34H41N5O6 (868286-82-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 50 h / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 18 h / 120 °C

3: lithium hydroxide; water / tetrahydrofuran / 50 h / 20 °C

4: 1-hydroxy-7-aza-benzotriazole; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 5 h / 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; water; sodium carbonate; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water;

upstream raw materials:

2-{3-[5-((1R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-5-[(dipropylamino)carbonyl]phenyl}-3-furoic acid

3-bromo-5-(5-((1R)-1-[(tert-butoxycarbonyl)amino]-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl)benzoic acid

tert-butyl [1-(5-{3-bromo-5-[(dipropylamino)carbonyl]phenyl}-1,3,4-oxadiazol-2-yl)-(1R)-1-methyl-2-phenylethyl]carbamate

methyl-2-{3-[5-((1R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-5-[(dipropylamino)carbonyl]phenyl}-3-furoate

Downstream raw materials:

C₃₄H₃₉N₅O₅