ethyl 2-(4-methoxyphenyl)-3-nitropropyl(diethoxymethyl)phosphinate

Base Information

• Chemical Name: ethyl 2-(4-methoxyphenyl)-3-nitropropyl(diethoxymethyl)phosphinate
• CAS No.: 125742-32-7
• Molecular Formula: C₁₇H₂₈NO₇P
• Molecular Weight: 389.386
• Mol file: 125742-32-7.mol

Synonyms:ethyl 2-(4-methoxyphenyl)-3-nitropropyl(diethoxymethyl)phosphinate

Chemical Property of ethyl 2-(4-methoxyphenyl)-3-nitropropyl(diethoxymethyl)phosphinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-methoxyphenyl)-3-nitropropyl(diethoxymethyl)phosphinate

There total 4 articles about ethyl 2-(4-methoxyphenyl)-3-nitropropyl(diethoxymethyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methoxy-4-(2-nitro-vinyl)-benzene (3179-10-0) + O-ethyl(methyl)diethoxymethyl phosphinate (112499-26-0) → ethyl 2-(4-methoxyphenyl)-3-nitropropyl(diethoxymethyl)phosphinate (125742-32-7)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

Reference yield:

orthoformic acid triethyl ester (122-51-0) → ethyl 2-(4-methoxyphenyl)-3-nitropropyl(diethoxymethyl)phosphinate (125742-32-7)

Guidance literature:

Multi-step reaction with 2 steps

2: LDA / tetrahydrofuran / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran;

Reference yield:

orthoformic acid triethyl ester (122-51-0) → ethyl 2-(4-methoxyphenyl)-3-nitropropyl(diethoxymethyl)phosphinate (125742-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 1 h / 0 °C

2: 1.) LDA / 1.) THF, -78 deg C, 1 h 2.) THF, -78 to 20 deg C

With lithium diisopropyl amide;

DOI:10.1016/S0040-4020(01)89240-1

upstream raw materials:

1-methoxy-4-(2-nitro-vinyl)-benzene

O-ethyl(methyl)diethoxymethyl phosphinate

(E)-1-methoxy-4-(2-nitrovinyl)benzene

orthoformic acid triethyl ester

Downstream raw materials:

ethyl 3-amino-2-(4-methoxyphenyl)propyl(diethoxymethyl)phosphinate

3-amino-2-(4-methoxyphenyl)propylphosphonous acid