(S)-3-(3-(2-chlorophenyl)propanoyl)-4-isopropyl-5,5-dimethyloxazolidin-2-one

Base Information

Chemical Name:(S)-3-(3-(2-chlorophenyl)propanoyl)-4-isopropyl-5,5-dimethyloxazolidin-2-one
CAS No.:1615694-07-9
Molecular Formula:C₁₇H₂₂ClNO₃
Molecular Weight:323.82
Hs Code.:

Synonyms:(S)-3-(3-(2-chlorophenyl)propanoyl)-4-isopropyl-5,5-dimethyloxazolidin-2-one

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Chemical Property of (S)-3-(3-(2-chlorophenyl)propanoyl)-4-isopropyl-5,5-dimethyloxazolidin-2-one

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Technology Process of (S)-3-(3-(2-chlorophenyl)propanoyl)-4-isopropyl-5,5-dimethyloxazolidin-2-one

There total 4 articles about (S)-3-(3-(2-chlorophenyl)propanoyl)-4-isopropyl-5,5-dimethyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 52085-97-9
3-(2-chlorophenyl)propionyl chloride

: 168297-86-7
(S)-4-isopropyl-5,5-dimethyloxazolidin-2-one

: 1615694-07-9
(S)-3-(3-(2-chlorophenyl)propanoyl)-4-isopropyl-5,5-dimethyloxazolidin-2-one

Guidance literature:: (S)-4-isopropyl-5,5-dimethyloxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

3-(2-chlorophenyl)propionyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo500957d

Reference yield:

: C₁₅H₂₆ClNO₅

: 1615694-07-9
(S)-3-(3-(2-chlorophenyl)propanoyl)-4-isopropyl-5,5-dimethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; diethyl ether / 48.17 h / 0 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 4 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo500957d

Reference yield:

: 1643-28-3
3-(2-chlorophenyl)propanoic acid

: 1615694-07-9
(S)-3-(3-(2-chlorophenyl)propanoyl)-4-isopropyl-5,5-dimethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; dichloromethane / 0.92 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo500957d