10-[3-(dimethylamino)propyl]-2-nitrodibenz[b,f][1,4]oxazepin-11(10H)-one monohydrochloride

Base Information

• Chemical Name: 10-[3-(dimethylamino)propyl]-2-nitrodibenz[b,f][1,4]oxazepin-11(10H)-one monohydrochloride
• CAS No.: 16398-39-3
• Molecular Formula: C18H19 N3 O4 . Cl H
• Molecular Weight: 377.827
• Mol file: 16398-39-3.mol

Synonyms:Dibenz[b,f][1,4]oxazepin-11(10H)-one,10-[3-(dimethylamino)propyl]-2-nitro-, monohydrochloride (8CI,9CI); CIBA2330Go; Nitroxazepine; Sintamil

Chemical Property of 10-[3-(dimethylamino)propyl]-2-nitrodibenz[b,f][1,4]oxazepin-11(10H)-one monohydrochloride

Chemical Property:

• Vapor Pressure: 1.09E-10mmHg at 25°C
• Melting Point: 227-229 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
• Boiling Point: 514.3°Cat760mmHg
• Flash Point: 264.8°C
• PSA: 78.60000
• Density: g/cm³
• LogP: 3.88720

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Nitroxazepine is an impurity of Amoxapine (A634230), which is an antidepressant.

Technology Process of 10-[3-(dimethylamino)propyl]-2-nitrodibenz[b,f][1,4]oxazepin-11(10H)-one monohydrochloride

There total 1 articles about 10-[3-(dimethylamino)propyl]-2-nitrodibenz[b,f][1,4]oxazepin-11(10H)-one monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 10-(3-dimethylamino-propyl)-2-nitro-10H-dibenzo[b,f][1,4]oxazepin-11-one; hydrochloride (16398-39-3)

Guidance literature:

Oxazepin I,Me2N-(CH2)3Cl*HCl II;

Reference yield:

10-(3-dimethylamino-propyl)-2-nitro-10H-dibenzo[b,f][1,4]oxazepin-11-one; hydrochloride (16398-39-3) → 1-methyl-1-[3-(2-nitro-11-oxo-11H-dibenzo[b,f][1,4]oxazepin-10-yl)-propyl]-3-phenyl-urea (54026-13-0)

Guidance literature:

Multi-step reaction with 3 steps

1: xylene / 7 h / Heating

2: HBr / acetic acid

3: benzene

With hydrogen bromide; In acetic acid; xylene; benzene;

Reference yield:

10-(3-dimethylamino-propyl)-2-nitro-10H-dibenzo[b,f][1,4]oxazepin-11-one; hydrochloride (16398-39-3) → 2-nitro-10-[3-(toluene-4-sulfonylamino)-propyl]-10H-dibenzo[b,f][1,4]oxazepin-11-one (54026-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ClCO₂Et / xylene / 7 h / Heating

2: dimethylformamide / 16 h / 110 °C

With chloroformic acid ethyl ester; In N,N-dimethyl-formamide; xylene;

Downstream raw materials:

1-methyl-1-[3-(2-nitro-11-oxo-11H-dibenzo[b,f][1,4]oxazepin-10-yl)-propyl]-3-phenyl-urea

2-nitro-10-[3-(toluene-4-sulfonylamino)-propyl]-10H-dibenzo[b,f][1,4]oxazepin-11-one

10-(3-dimethylaminopropyl)-2-nitro-10,11-dihydrodibenz<1,4>oxazepin-11-one