(2R,3S,4R,5R,6S)-3,4,5,6-tetrahydro-3-(2-bromopropanoyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2-vinyl-2H-pyran

Base Information

• Chemical Name: (2R,3S,4R,5R,6S)-3,4,5,6-tetrahydro-3-(2-bromopropanoyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2-vinyl-2H-pyran
• CAS No.: 1039034-53-1
• Molecular Formula: C₂₁H₂₉BrO₅
• Molecular Weight: 441.362
• Mol file: 1039034-53-1.mol

Synonyms:(2R,3S,4R,5R,6S)-3,4,5,6-tetrahydro-3-(2-bromopropanoyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2-vinyl-2H-pyran

Chemical Property of (2R,3S,4R,5R,6S)-3,4,5,6-tetrahydro-3-(2-bromopropanoyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2-vinyl-2H-pyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (2R,3S,4R,5R,6S)-3,4,5,6-tetrahydro-3-(2-bromopropanoyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2-vinyl-2H-pyran

There total 1 articles about (2R,3S,4R,5R,6S)-3,4,5,6-tetrahydro-3-(2-bromopropanoyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2-vinyl-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(2R,3S,4S,5R,6S)-3,4,5,6-tetrahydro-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2-vinyl-2H-pyran-3-ol (1039034-35-9) + 2-Bromopropionic acid (598-72-1,10327-08-9) → (2R,3S,4R,5R,6S)-3,4,5,6-tetrahydro-3-(2-bromopropanoyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2-vinyl-2H-pyran (1039034-53-1)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 13h; Inert atmosphere;

DOI:10.1021/ol801066y

Reference yield: 87.0%

(2R,3S,4R,5R,6S)-3,4,5,6-tetrahydro-3-(2-bromopropanoyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2-vinyl-2H-pyran (1039034-53-1) → (2S,3S,4R,5R,6S)-3,4,5,6-tetrahydro-3-(2-bromopropanoyloxy)-2-formyl-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2H-pyran (1039034-36-0)

Guidance literature:

(2R,3S,4R,5R,6S)-3,4,5,6-tetrahydro-3-(2-bromopropanoyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2-vinyl-2H-pyran; With ozone; In methanol; at -78 ℃; for 0.75h;

With triphenylphosphine; In methanol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol801066y

upstream raw materials:

(2R,3S,4S,5R,6S)-3,4,5,6-tetrahydro-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2-vinyl-2H-pyran-3-ol

2-Bromopropionic acid

Downstream raw materials:

(2S,3S,4R,5R,6S)-3,4,5,6-tetrahydro-3-(2-bromopropanoyloxy)-2-formyl-5-(4-methoxybenzyloxy)-2,4,6-trimethyl-2H-pyran