dimethyl 2‐{(S)‐(4‐cyanophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

Base Information

Chemical Name:dimethyl 2‐{(S)‐(4‐cyanophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate
CAS No.:1398508-08-1
Molecular Formula:C₁₉H₂₁NO₅
Molecular Weight:343.379
Hs Code.:

Synonyms:dimethyl 2‐{(S)‐(4‐cyanophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

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Chemical Property of dimethyl 2‐{(S)‐(4‐cyanophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

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Technology Process of dimethyl 2‐{(S)‐(4‐cyanophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

There total 5 articles about dimethyl 2‐{(S)‐(4‐cyanophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 93098-69-2
2–(4–cyanobenzylidene)dimethyl malonate

: 1398508-08-1
dimethyl 2‐{(S)‐(4‐cyanophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

Guidance literature:: cyclohexanone; With silver hexafluoroantimonate; (2S)-2-amino-3,3-dimethyl-N-(pyridin-2-yl)butanamide; zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 3h;

2–(4–cyanobenzylidene)dimethyl malonate; In tetrahydrofuran; at 20 ℃; for 96h; enantioselective reaction;
DOI:10.1021/jo301070s

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 93098-69-2
2–(4–cyanobenzylidene)dimethyl malonate

: 1398508-08-1
dimethyl 2‐{(S)‐(4‐cyanophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

: dimethyl 2-((R)-(4-cyanophenyl)((R)-2-oxocyclohexyl)methyl)malonate

: dimethyl 2-(4-cyanophenyl)-(2-oxocyclohexyl)methylmalonate

Guidance literature:: With (S)-2-((naphthalen-2-ylthio)methyl)pyrrolidine; In ethyl acetate; at 35 ℃; for 192h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/chir.22055

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 93098-69-2
2–(4–cyanobenzylidene)dimethyl malonate

: 1398508-08-1
dimethyl 2‐{(S)‐(4‐cyanophenyl)[(1S)‐2‐oxocyclohexyl]methyl}propanedioate

: dimethyl 2-((R)-(4-cyanophenyl)((R)-2-oxocyclohexyl)methyl)malonate

: C₁₉H₂₁NO₅

Guidance literature:: With C₁₅H₂₃F₉N₄O₂S₂; In water; at 20 ℃; for 48h; Overall yield = 81 %; enantioselective reaction;
DOI:10.1002/chir.23015