(4S,6S)-7-[ (2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-4-hydroxy-1-{(4S,6R)-6-[ (3S,4S,E)-4-hydroxy-3,5-dimethylhex-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl}-6-(4-methoxybenzyloxy)heptan-2-one

Base Information

Chemical Name:(4S,6S)-7-[ (2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-4-hydroxy-1-{(4S,6R)-6-[ (3S,4S,E)-4-hydroxy-3,5-dimethylhex-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl}-6-(4-methoxybenzyloxy)heptan-2-one
CAS No.:1333473-63-4
Molecular Formula:C₅₁H₇₆O₁₂
Molecular Weight:881.157
Hs Code.:

(4S,6S)-7-[ (2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-4-hydroxy-1-{(4S,6R)-6-[ (3S,4S,E)-4-hydroxy-3,5-dimethylhex-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl}-6-(4-methoxybenzyloxy)heptan-2-one

Synonyms:(4S,6S)-7-[ (2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-4-hydroxy-1-{(4S,6R)-6-[ (3S,4S,E)-4-hydroxy-3,5-dimethylhex-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl}-6-(4-methoxybenzyloxy)heptan-2-one

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Chemical Property of (4S,6S)-7-[ (2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-4-hydroxy-1-{(4S,6R)-6-[ (3S,4S,E)-4-hydroxy-3,5-dimethylhex-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl}-6-(4-methoxybenzyloxy)heptan-2-one

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Technology Process of (4S,6S)-7-[ (2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-4-hydroxy-1-{(4S,6R)-6-[ (3S,4S,E)-4-hydroxy-3,5-dimethylhex-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl}-6-(4-methoxybenzyloxy)heptan-2-one

There total 9 articles about (4S,6S)-7-[ (2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-4-hydroxy-1-{(4S,6R)-6-[ (3S,4S,E)-4-hydroxy-3,5-dimethylhex-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl}-6-(4-methoxybenzyloxy)heptan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₃₀O₄

: 1333473-62-3
(R)-4-[(2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]-methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-3-(4-methoxybenzyloxy)-butanal

: 1333473-63-4
(4S,6S)-7-[ (2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-4-hydroxy-1-{(4S,6R)-6-[ (3S,4S,E)-4-hydroxy-3,5-dimethylhex-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl}-6-(4-methoxybenzyloxy)heptan-2-one

: C₅₁H₇₆O₁₂

Guidance literature:: C₁₇H₃₀O₄; With dicyclohexylboron chloride; triethylamine; In diethyl ether; at -10 ℃; for 0.833333h;

(R)-4-[(2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]-methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-3-(4-methoxybenzyloxy)-butanal; In diethyl ether; at -78 - -26 ℃; for 31.0833h; optical yield given as %de;
DOI:10.1021/jo2012658

Reference yield:

: 1333473-61-2
(4S,5S,6R)-4-allyl-6-{[(2R,4R,6R)-2-(4-methoxyphenyl)-6-{[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]methyl}-1,3-dioxan-4-yl]methyl}-2,2,5-trimethyl-1,3-dioxane

: 1333473-63-4
(4S,6S)-7-[ (2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-4-hydroxy-1-{(4S,6R)-6-[ (3S,4S,E)-4-hydroxy-3,5-dimethylhex-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl}-6-(4-methoxybenzyloxy)heptan-2-one

: C₅₁H₇₆O₁₂

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / dichloromethane / 4.25 h / 0 - 20 °C

1.2: 2 h / Saturated solution

2.1: potassium carbonate; Dess-Martin periodane / dichloromethane / 15 h / 0 - 20 °C

3.1: dicyclohexylboron chloride; triethylamine / diethyl ether / 0.83 h / -10 °C

3.2: 31.08 h / -78 - -26 °C

With dicyclohexylboron chloride; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jo2012658

Reference yield:

: 1333473-59-8
C₃₇H₅₄O₈Si

: 1333473-63-4
(4S,6S)-7-[ (2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-4-hydroxy-1-{(4S,6R)-6-[ (3S,4S,E)-4-hydroxy-3,5-dimethylhex-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl}-6-(4-methoxybenzyloxy)heptan-2-one

: C₅₁H₇₆O₁₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / methanol / 15 h / -50 °C

1.2: Saturated solution

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C

3.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / 20 °C

4.1: diisobutylaluminium hydride / dichloromethane / 4.25 h / 0 - 20 °C

4.2: 2 h / Saturated solution

5.1: potassium carbonate; Dess-Martin periodane / dichloromethane / 15 h / 0 - 20 °C

6.1: dicyclohexylboron chloride; triethylamine / diethyl ether / 0.83 h / -10 °C

6.2: 31.08 h / -78 - -26 °C

With sodium tetrahydroborate; dicyclohexylboron chloride; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo2012658