Technology Process of (R)-5-O-benzyl-<2-2H>mevalonic acid
There total 13 articles about (R)-5-O-benzyl-<2-2H>mevalonic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
jones' reagent;
In
acetone;
- Guidance literature:
-
With
sodium chlorite; 2-methyl-but-2-ene;
In
aq. phosphate buffer; tert-butyl alcohol;
at 20 ℃;
for 3h;
DOI:10.1039/c3ob41755g
- Guidance literature:
-
Multi-step reaction with 4 steps
1: D-(-)-diisopropyl tartrate; titanium(IV) isopropylate; Cumene hydroperoxide / dichloromethane / -23 °C / Molecular sieve
2: lithium aluminium deuteride / tetrahydrofuran; diethyl ether / 3 h / 0 °C
3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C
4: sodium chlorite; 2-methyl-but-2-ene / tert-butyl alcohol; aq. phosphate buffer / 3 h / 20 °C
With
titanium(IV) isopropylate; sodium chlorite; lithium aluminium deuteride; 2-methyl-but-2-ene; Cumene hydroperoxide; D-(-)-diisopropyl tartrate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; aq. phosphate buffer; diethyl ether; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol;
1: |Sharpless Asymmetric Epoxidation;
DOI:10.1039/c3ob41755g
