6-(((3S)-3-(1-propyn-1-yl)-4-(4-(R)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine

Base Information

Chemical Name:6-(((3S)-3-(1-propyn-1-yl)-4-(4-(R)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine
CAS No.:1572927-51-5
Molecular Formula:C₁₈H₁₉F₃N₆O₃S₂
Molecular Weight:488.514
Hs Code.:

Synonyms:6-(((3S)-3-(1-propyn-1-yl)-4-(4-(R)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine

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Chemical Property of 6-(((3S)-3-(1-propyn-1-yl)-4-(4-(R)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine

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Technology Process of 6-(((3S)-3-(1-propyn-1-yl)-4-(4-(R)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine

There total 16 articles about 6-(((3S)-3-(1-propyn-1-yl)-4-(4-(R)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₇F₃N₆O₅S₂

: 1572927-50-4
6-(((3S)-3-(1-propyn-1-yl)-4-(4-(S)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine

: 1572927-51-5
6-(((3S)-3-(1-propyn-1-yl)-4-(4-(R)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.666667h;

Reference yield:

: 1572928-39-2
(2S)-4-benzyl-2-(1-propyn-1-yl)-1-(4-(S-(trifluoromethyl)sulfonimidoyl)phenyl)piperazine

: 1572927-50-4
6-(((3S)-3-(1-propyn-1-yl)-4-(4-(S)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine

: 1572927-51-5
6-(((3S)-3-(1-propyn-1-yl)-4-(4-(R)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 2.5 h / 20 °C

1.2: 0.75 h / 70 °C

2.1: triethylamine / dichloromethane / 1 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1450621-78-9
(3S)-1-benzyl-3-(2-propyn-1-yl)-2,5-piperazinedione

: 1572927-50-4
6-(((3S)-3-(1-propyn-1-yl)-4-(4-(S)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine

: 1572927-51-5
6-(((3S)-3-(1-propyn-1-yl)-4-(4-(R)-S-((trifluoromethyl)sulfonimidoyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridazinamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

3.1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); sodium t-butanolate; ruphos / 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere

4.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 2.5 h / 20 °C

4.2: 0.75 h / 70 °C

5.1: triethylamine / dichloromethane / 1 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

With lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); potassium tert-butylate; potassium carbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;