3-{4-chloro-3-[(2Z)-4-oxo-2-(phenylimino)-1,3-thiazolidin-3-yl]phenyl}-2-(4-{[(E)-(4-chlorophenyl)methylidene]amino}phenyl)quinazolin-4(3H)-one

Base Information

Chemical Name:3-{4-chloro-3-[(2Z)-4-oxo-2-(phenylimino)-1,3-thiazolidin-3-yl]phenyl}-2-(4-{[(E)-(4-chlorophenyl)methylidene]amino}phenyl)quinazolin-4(3H)-one
CAS No.:83408-75-7
Molecular Formula:C₃₆H₂₃Cl₂N₅O₂S
Molecular Weight:660.583
Hs Code.:

3-{4-chloro-3-[(2Z)-4-oxo-2-(phenylimino)-1,3-thiazolidin-3-yl]phenyl}-2-(4-{[(E)-(4-chlorophenyl)methylidene]amino}phenyl)quinazolin-4(3H)-one

Synonyms:

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Chemical Property of 3-{4-chloro-3-[(2Z)-4-oxo-2-(phenylimino)-1,3-thiazolidin-3-yl]phenyl}-2-(4-{[(E)-(4-chlorophenyl)methylidene]amino}phenyl)quinazolin-4(3H)-one

Chemical Property:

Vapor Pressure:3.52E-28mmHg at 25°C
Boiling Point:836.5°Cat760mmHg
Flash Point:459.7°C
Density:1.39g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-{4-chloro-3-[(2Z)-4-oxo-2-(phenylimino)-1,3-thiazolidin-3-yl]phenyl}-2-(4-{[(E)-(4-chlorophenyl)methylidene]amino}phenyl)quinazolin-4(3H)-one

There total 7 articles about 3-{4-chloro-3-[(2Z)-4-oxo-2-(phenylimino)-1,3-thiazolidin-3-yl]phenyl}-2-(4-{[(E)-(4-chlorophenyl)methylidene]amino}phenyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 83408-69-9
1-{2-Chloro-5-[2-(4-{[1-(4-chloro-phenyl)-meth-(E)-ylidene]-amino}-phenyl)-4-oxo-4H-quinazolin-3-yl]-phenyl}-3-phenyl-thiourea

: 79-11-8
chloroacetic acid

: 83408-75-7
3-(4-Chloro-3-{4-oxo-2-[(Z)-phenylimino]-thiazolidin-3-yl}-phenyl)-2-(4-{[1-(4-chloro-phenyl)-meth-(E)-ylidene]-amino}-phenyl)-3H-quinazolin-4-one

Guidance literature:: With sodium acetate; acetic acid; for 6h; Heating;

Reference yield:

: 635-22-3
4-Chloro-3-nitroaniline

: 83408-75-7
3-(4-Chloro-3-{4-oxo-2-[(Z)-phenylimino]-thiazolidin-3-yl}-phenyl)-2-(4-{[1-(4-chloro-phenyl)-meth-(E)-ylidene]-amino}-phenyl)-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / 0.25 h / Heating

2: 58 percent / N₂H₄*H₂O / Raney nickel / ethanol / 12 h / Heating

3: 60 percent / benzene / 4 h / Heating

4: 58 percent / NaOAc, glacial AcOH / 6 h / Heating

With sodium acetate; hydrazine hydrate; acetic acid; nickel; In ethanol; benzene;

Reference yield:

: 3996-26-7
N-(p-chlorobenzylidene)-p-aminobenzoic acid

: 83408-75-7
3-(4-Chloro-3-{4-oxo-2-[(Z)-phenylimino]-thiazolidin-3-yl}-phenyl)-2-(4-{[1-(4-chloro-phenyl)-meth-(E)-ylidene]-amino}-phenyl)-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂

2: 75 percent / pyridine / 1 h / 10 °C

3: 60 percent / 0.25 h / Heating

4: 58 percent / N₂H₄*H₂O / Raney nickel / ethanol / 12 h / Heating

5: 60 percent / benzene / 4 h / Heating

6: 58 percent / NaOAc, glacial AcOH / 6 h / Heating

With pyridine; thionyl chloride; sodium acetate; hydrazine hydrate; acetic acid; nickel; In ethanol; benzene;