3-chloro-trans-cinnamic acid n-butyl ester

Base Information

• Chemical Name: 3-chloro-trans-cinnamic acid n-butyl ester
• CAS No.: 131061-13-7
• Molecular Formula: C₁₃H₁₅ClO₂
• Molecular Weight: 238.714
• Mol file: 131061-13-7.mol

Synonyms:3-chloro-trans-cinnamic acid n-butyl ester

Chemical Property of 3-chloro-trans-cinnamic acid n-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-chloro-trans-cinnamic acid n-butyl ester

There total 7 articles about 3-chloro-trans-cinnamic acid n-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-bromo-3-chlorobenzene (108-37-2) + acrylic acid n-butyl ester (141-32-2,9003-49-0) → 3-chloro-trans-cinnamic acid n-butyl ester (131061-13-7)

Guidance literature:

With potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; 3-(2,6-diisopropylphenyl)-1-(2-diphenylphosphanylbenzyl)-3H-imidazol-1-ium chloride; In N,N-dimethyl acetamide; at 120 ℃; for 5h;

DOI:10.1016/j.tet.2004.10.049

Reference yield: 99.0%

acrylic acid n-butyl ester (141-32-2,9003-49-0) + 3-iodochlorobenzene (625-99-0) → 3-chloro-trans-cinnamic acid n-butyl ester (131061-13-7)

Guidance literature:

With triethylamine; bis(N-methylimidazol-2-yl)Pd(Cl)Me; In various solvent(s); at 120 ℃; for 1h;

DOI:10.1021/ol030071d

Reference yield: 83.0%

acrylic acid n-butyl ester (141-32-2,9003-49-0) + sodium 3-chlorobenzenesulfinate (15946-37-9) → 3-chloro-trans-cinnamic acid n-butyl ester (131061-13-7)

Guidance literature:

With copper diacetate; palladium diacetate; In tetrahydrofuran; dimethyl sulfoxide; at 70 ℃; for 6h; stereoselective reaction;

DOI:10.1002/aoc.2970

upstream raw materials:

acrylic acid n-butyl ester

3-chlorophenylsulfonyl chloride

3-chlorophenylboronic acid

3-iodochlorobenzene

Downstream raw materials:

(E)-n-butyl 3-(3-((E)-styryl)phenyl)acrylate