tert-butyl N-{1-[4-(5-isoxazolyl) phenyl]-1-methylethyl}carbamate

Base Information

Chemical Name:tert-butyl N-{1-[4-(5-isoxazolyl) phenyl]-1-methylethyl}carbamate
CAS No.:314268-43-4
Molecular Formula:C₁₇H₂₂N₂O₃
Molecular Weight:302.373
Hs Code.:
European Community (EC) Number:844-737-3

Synonyms:314268-43-4;tert-butyl N-{1-[4-(5-isoxazolyl) phenyl]-1-methylethyl}carbamate;tert-butyl N-[2-[4-(1,2-oxazol-5-yl)phenyl]propan-2-yl]carbamate;tert-butyl N-{2-[4-(1,2-oxazol-5-yl)phenyl]propan-2-yl}carbamate;SCHEMBL6034612;CTCSPPPTIGUELG-UHFFFAOYSA-N;EN300-7464843;tert-butyl N-{1-[4-(5-isoxazolyl)phenyl]-1-methylethyl}carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl N-{1-[4-(5-isoxazolyl) phenyl]-1-methylethyl}carbamate

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:302.16304257
Heavy Atom Count:22
Complexity:382

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(C)(C)C1=CC=C(C=C1)C2=CC=NO2

Technology Process of tert-butyl N-{1-[4-(5-isoxazolyl) phenyl]-1-methylethyl}carbamate

There total 1 articles about tert-butyl N-{1-[4-(5-isoxazolyl) phenyl]-1-methylethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 314267-84-0
1-[4-(5-isoxazolyl)phenyl]-1-methylethylamine

: 24424-99-5
di-tert-butyl dicarbonate

: 314268-43-4
1,1-dimethylethyl[1-[4-(5-isoxazolyl)phenyl]-1-methylethyl]carbamate

Guidance literature:: In toluene; Heating;
DOI:10.1016/j.bmcl.2007.04.021

Reference yield: 92.0%

: 314268-43-4
1,1-dimethylethyl[1-[4-(5-isoxazolyl)phenyl]-1-methylethyl]carbamate

: 314268-44-5
1,1-dimethylethyl [1-[4-(cyanoacetyl)phenyl]-1-methylethyl]carbamate

Guidance literature:: With sodium hydroxide; In ethanol; at 25 ℃;
DOI:10.1016/j.bmcl.2007.04.021

Reference yield:

: 314268-43-4
1,1-dimethylethyl[1-[4-(5-isoxazolyl)phenyl]-1-methylethyl]carbamate

: 314268-15-0
4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-5-cyano-N-[3-(2-morpholinoethyl)phenyl]pyrimidine-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / NaOH / ethanol / 25 °C

2: dimethylformamide / 25 °C

3: NaHCO₃ / dimethylformamide / 100 °C

4: dimethylformamide / 60 °C

With sodium hydroxide; sodium hydrogencarbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.04.021