{(S)-1-[(S)-1-(2-Chloro-acetyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{(S)-1-[(S)-1-(2-Chloro-acetyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester
CAS No.:77076-37-0
Molecular Formula:C₂₁H₃₁ClN₂O₄
Molecular Weight:410.941
Hs Code.:

Synonyms:{(S)-1-[(S)-1-(2-Chloro-acetyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {(S)-1-[(S)-1-(2-Chloro-acetyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {(S)-1-[(S)-1-(2-Chloro-acetyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

There total 4 articles about {(S)-1-[(S)-1-(2-Chloro-acetyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.8%

: 67729-36-6,60398-40-5
Boc-Phe-O-COO-isoBu

: 54518-92-2
Leu-chloromethyl ketone hydrochloride

: 77076-37-0
{(S)-1-[(S)-1-(2-Chloro-acetyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1248/cpb.41.2038

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 54518-92-2
Leu-chloromethyl ketone hydrochloride

: 77076-37-0
{(S)-1-[(S)-1-(2-Chloro-acetyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; isobutyl chloroformate; In tetrahydrofuran; Yield given;
DOI:10.1016/0040-4039(94)88031-X

Reference yield:

: 75899-20-6,148854-05-1
(C₅H₉O₂)(NHCHCOO)(CH₂C₃H₇)(CO₂C₂H₅)

: 77076-37-0
{(S)-1-[(S)-1-(2-Chloro-acetyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) 7.6N HCl/dioxane / 1.) THF, 4 deg C, overnight, 2.) THF, 0 deg C, 3 h

2: 7.6N HCl/dioxane / dimethylformamide / 3 h / 0 °C

3: 51.8 percent / Et₃N / tetrahydrofuran; dimethylformamide / 0 - 20 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.41.2038