alpha-(2,6-Dichlorophenyl)-6-(phenylthio)-3-pyridazineacetonitrile

Base Information

Chemical Name:alpha-(2,6-Dichlorophenyl)-6-(phenylthio)-3-pyridazineacetonitrile
CAS No.:209412-07-7
Molecular Formula:C₁₈H₁₁Cl₂N₃S
Molecular Weight:372.277
Hs Code.:
DSSTox Substance ID:DTXSID901179483

Synonyms:209412-07-7;SCHEMBL12139918;DTXSID901179483;alpha-(2,6-Dichlorophenyl)-6-(phenylthio)-3-pyridazineacetonitrile;AKOS004909663

Suppliers and Price of alpha-(2,6-Dichlorophenyl)-6-(phenylthio)-3-pyridazineacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of alpha-(2,6-Dichlorophenyl)-6-(phenylthio)-3-pyridazineacetonitrile

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:371.0050739
Heavy Atom Count:24
Complexity:439

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)SC2=NN=C(C=C2)C(C#N)C3=C(C=CC=C3Cl)Cl

Technology Process of alpha-(2,6-Dichlorophenyl)-6-(phenylthio)-3-pyridazineacetonitrile

There total 2 articles about alpha-(2,6-Dichlorophenyl)-6-(phenylthio)-3-pyridazineacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 108-98-5
thiophenol

: 209412-06-6
6-chloro-α-(2,6-dichlorophenyl)pyridazine-3-acetonitrile

: 209412-07-7
α-(2,6-dichlorophenyl)-6-(phenylthio)pyridazine-3-acetonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 0.75h;
DOI:10.3390/61200959

Reference yield:

: 3215-64-3
2,6-dichlorophenylacetonitrile

: 209412-07-7
α-(2,6-dichlorophenyl)-6-(phenylthio)pyridazine-3-acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 43 percent / tetrahydrofuran / 0.5 h / 20 °C

2.1: 72 percent / sodium hydride / dimethylformamide / 0.75 h / 100 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.3390/61200959