N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-2-(4-chlorophenyl)acetamide

Base Information

• Chemical Name: N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-2-(4-chlorophenyl)acetamide
• CAS No.: 1477751-40-8
• Molecular Formula: C₂₂H₁₆BrClN₄O
• Molecular Weight: 467.752
• Mol file: 1477751-40-8.mol

Synonyms:N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-2-(4-chlorophenyl)acetamide

Chemical Property of N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-2-(4-chlorophenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-2-(4-chlorophenyl)acetamide

There total 4 articles about N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-2-(4-chlorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-chlorophenacetyl chloride (25026-34-0) + 6-amino-4-[(3-bromophenyl)amino]quinazoline (169205-78-1) → N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-2-(4-chlorophenyl)acetamide (1477751-40-8)

Guidance literature:

With potassium carbonate; In ethyl acetate; at 0 ℃;

DOI:10.1039/c3ra45204b

Reference yield:

5-nitroanthranilonitrile (17420-30-3) → N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-2-(4-chlorophenyl)acetamide (1477751-40-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 2 h / 70 - 80 °C

2: acetic acid / 2 h / Reflux

3: acetic acid; iron / water; ethanol / 70 - 80 °C

4: potassium carbonate / ethyl acetate / 0 °C

With iron; potassium carbonate; acetic acid; In ethanol; water; ethyl acetate;

DOI:10.1039/c3ra45204b

Reference yield:

N′-(2-cyano-4-nitrophenyl)-N,N-dimethylformimidamide (39263-34-8) → N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-2-(4-chlorophenyl)acetamide (1477751-40-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 2 h / Reflux

2: acetic acid; iron / water; ethanol / 70 - 80 °C

3: potassium carbonate / ethyl acetate / 0 °C

With iron; potassium carbonate; acetic acid; In ethanol; water; ethyl acetate;

DOI:10.1039/c3ra45204b

upstream raw materials:

4-chlorophenacetyl chloride

6-amino-4-[(3-bromophenyl)amino]quinazoline

5-nitroanthranilonitrile

N′-(2-cyano-4-nitrophenyl)-N,N-dimethylformimidamide