methyl N-[(hex-5-en-1-yloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

Base Information

• Chemical Name: methyl N-[(hex-5-en-1-yloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate
• CAS No.: 1020094-24-9
• Molecular Formula: C₃₆H₄₃N₃O₆
• Molecular Weight: 613.754
• Mol file: 1020094-24-9.mol

Synonyms:methyl N-[(hex-5-en-1-yloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

Chemical Property of methyl N-[(hex-5-en-1-yloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-[(hex-5-en-1-yloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate

There total 1 articles about methyl N-[(hex-5-en-1-yloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H22N2O3 (914980-21-5) + N-[(hex-5-en-1-yloxy)carbonyl]-L-norleucine (914839-35-3) → methyl N-[(hex-5-en-1-yloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate (1020094-24-9)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1021/ja711120r

Reference yield: 86.0%

methyl N-[(hex-5-en-1-yloxy)carbonyl]-L-norleucyl-(4R)-4-[(2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolinate (1020094-24-9) → methyl (3R,5S,8S,16E)-8-butyl-7,10-dioxo-23-phenyl-2,11-dioxa-6,9,22-triazatetracyclo[16.6.2.1-3,6-.0-21,25-]heptacosa-1(24),16,18,20,22,25-hexaene-5-carboxylate (1020094-32-9)

Guidance literature:

bis(Me₃Ph)imidazole[(iPrO)(Me₂NSO₂)Ph]methyleneRu(II)Cl₂; In 1,2-dichloro-ethane; at 20 ℃; for 24h;

DOI:10.1021/ja711120r

upstream raw materials:

C₂₃H₂₂N₂O₃

N-[(hex-5-en-1-yloxy)carbonyl]-L-norleucine

Downstream raw materials:

methyl (3R,5S,8S,16E)-8-butyl-7,10-dioxo-23-phenyl-2,11-dioxa-6,9,22-triazatetracyclo[16.6.2.1-3,6-.0-21,25-]heptacosa-1⁽²⁴⁾,16,18,20,22,25-hexaene-5-carboxylate