1,5,9,14-Tetraazabicyclo[12.3.1]octadecane-4,18-dione,9-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-2-phenyl-, (2S)-

Base Information

Chemical Name:1,5,9,14-Tetraazabicyclo[12.3.1]octadecane-4,18-dione,9-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-2-phenyl-, (2S)-
CAS No.:12651-38-6
Molecular Formula:C29H36 N4 O3
Molecular Weight:488.63
Hs Code.:

Synonyms:1,5,9,14-Tetraazabicyclo[12.3.1]octadecane-4,18-dione,9-(1-oxo-3-phenyl-2-propenyl)-2-phenyl-, [S-(E)]-;1,5,9,14-Tetraazabicyclo[12.3.1]octadecane-4,18-dione,9-[(2E)-1-oxo-3-phenyl-2-propenyl]-2-phenyl-, (2S)- (9CI); Verbascine;Verbaskine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,5,9,14-Tetraazabicyclo[12.3.1]octadecane-4,18-dione,9-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-2-phenyl-, (2S)-

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,5,9,14-Tetraazabicyclo[12.3.1]octadecane-4,18-dione,9-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-2-phenyl-, (2S)-

There total 15 articles about 1,5,9,14-Tetraazabicyclo[12.3.1]octadecane-4,18-dione,9-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-2-phenyl-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 174393-34-1
(+/-)-verbacine

: 12651-38-6
(+/-)-verbaskine

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1021/ja953541a

Reference yield:

: 71-44-3
Spermine

: 12651-38-6
(+/-)-verbaskine

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) H₂, CHCl₃ / 2.) PtO₂

2: 90 percent / Sb(OEt)3 / benzene / 9 h / 80 °C

3: 1.) (3,5-bis(trifluoromethyl)phenyl)boronic acid / 1.) CH₂Cl₂, from -78 deg C to RT, 2.) CH₂Cl₂, -78 deg C

4: 78 percent / triethylamine / CH₂Cl₂ / Ambient temperature

With chloroform; triethoxyantimony; hydrogen; triethylamine; 3,5-bis-trifluromethylphenylboronic acid; platinum(IV) oxide; In dichloromethane; benzene;
DOI:10.1021/ja953541a

Reference yield:

: 2216-94-6
phenylpropynoic acid ethyl ester

: 12651-38-6
(+/-)-verbaskine

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) H₂, CHCl₃ / 2.) PtO₂

2: 90 percent / Sb(OEt)3 / benzene / 9 h / 80 °C

3: 1.) (3,5-bis(trifluoromethyl)phenyl)boronic acid / 1.) CH₂Cl₂, from -78 deg C to RT, 2.) CH₂Cl₂, -78 deg C

4: 78 percent / triethylamine / CH₂Cl₂ / Ambient temperature

With chloroform; triethoxyantimony; hydrogen; triethylamine; 3,5-bis-trifluromethylphenylboronic acid; platinum(IV) oxide; In dichloromethane; benzene;
DOI:10.1021/ja953541a