2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

Base Information

Chemical Name:2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide
CAS No.:479195-09-0
Molecular Formula:C₂₆H₂₆BrF₆NO₃
Molecular Weight:594.392
Hs Code.:

2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-<i>N</i>-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

Synonyms:2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

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Chemical Property of 2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

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Technology Process of 2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

There total 6 articles about 2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 479195-06-7
2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

: 479195-09-0
2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

Guidance literature:: With 2,6-di-tert-butyl-4-methylpyridine; carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2005.11.111

Reference yield:

: 877056-25-2
2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoyl chloride

: 479195-09-0
2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 60 percent / pyridine / CH₂Cl₂

2.1: 98 percent / p-TSA / toluene

3.1: O₃

3.2: 83 percent / NaBH₄ / methanol; CH₂Cl₂

4.1: 76 percent / PPh₃; 2,6-di-tert-butyl-4-picoline; CBr₄ / CH₂Cl₂ / 20 °C

With pyridine; 2,6-di-tert-butyl-4-methylpyridine; carbon tetrabromide; toluene-4-sulfonic acid; ozone; triphenylphosphine; In dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.11.111

Reference yield:

: 334477-38-2
(RS)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetic acid

: 479195-09-0
2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / (CO₂Cl)2

2.1: 60 percent / pyridine / CH₂Cl₂

3.1: 98 percent / p-TSA / toluene

4.1: O₃

4.2: 83 percent / NaBH₄ / methanol; CH₂Cl₂

5.1: 76 percent / PPh₃; 2,6-di-tert-butyl-4-picoline; CBr₄ / CH₂Cl₂ / 20 °C

With pyridine; 2,6-di-tert-butyl-4-methylpyridine; carbon tetrabromide; (CO₂Cl)2; toluene-4-sulfonic acid; ozone; triphenylphosphine; In dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.11.111