(RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-methyl-phenyl)acetic acid

Base Information

Chemical Name:(RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-methyl-phenyl)acetic acid
CAS No.:181037-94-5
Molecular Formula:C₂₁H₁₇NO₄S
Molecular Weight:379.436
Hs Code.:

Synonyms:(RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-methyl-phenyl)acetic acid

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Chemical Property of (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-methyl-phenyl)acetic acid

Chemical Property:

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Technology Process of (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-methyl-phenyl)acetic acid

There total 11 articles about (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-methyl-phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181040-06-2
methyl (RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-methylphenyl)acetate

: 181037-94-5
(RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-methyl-phenyl)acetic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1021/jm990378b

Reference yield:

: 644-36-0
o-methylphenylacetic acid

: 181037-94-5
(RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-methyl-phenyl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂SO₄ / Heating

2.1: NBS; AIBN / CHCl₃ / Heating

3.1: NaH / dimethylformamide / 0.17 h / 20 °C

3.2: dimethylformamide / 1 h / 20 °C

4.1: 1M NaOH / dioxane / 1 h / 20 °C

With sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; sodium hydride; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide; 1.1: Esterification / 2.1: Bromination / 3.1: Metallation / 3.2: Substitution / 4.1: Hydrolysis;
DOI:10.1021/jm990378b

Reference yield:

: 40851-62-5
methyl o-tolylacetate

: 181037-94-5
(RS)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]-(2-methyl-phenyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: NBS; AIBN / CHCl₃ / Heating

2.1: NaH / dimethylformamide / 0.17 h / 20 °C

2.2: dimethylformamide / 1 h / 20 °C

3.1: 1M NaOH / dioxane / 1 h / 20 °C

With sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide; 1.1: Bromination / 2.1: Metallation / 2.2: Substitution / 3.1: Hydrolysis;
DOI:10.1021/jm990378b