4-[(2S,3S)-3-Ethyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-3-propyl-azetidin-2-yloxy]-benzoic acid tert-butyl ester

Base Information

• Chemical Name: 4-[(2S,3S)-3-Ethyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-3-propyl-azetidin-2-yloxy]-benzoic acid tert-butyl ester
• CAS No.: 1026124-62-8
• Molecular Formula: C₂₈H₃₆N₂O₅
• Molecular Weight: 480.604

Synonyms:4-[(2S,3S)-3-Ethyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-3-propyl-azetidin-2-yloxy]-benzoic acid tert-butyl ester

Chemical Property of 4-[(2S,3S)-3-Ethyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-3-propyl-azetidin-2-yloxy]-benzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(2S,3S)-3-Ethyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-3-propyl-azetidin-2-yloxy]-benzoic acid tert-butyl ester

There total 5 articles about 4-[(2S,3S)-3-Ethyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-3-propyl-azetidin-2-yloxy]-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R)-1-phenylethyl isocyanate (33375-06-3) + (3S,4S)-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-3-ethyl-3-propylazetidin-2-one (164033-14-1) → 4-[(2S,3S)-3-Ethyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-3-propyl-azetidin-2-yloxy]-benzoic acid tert-butyl ester (1026124-62-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 25 - 50 ℃; for 19.5h;

DOI:10.1021/jm00013a021

Reference yield:

tert-butyl 4-hydroxybenzoate (25804-49-3) → 4-[(2S,3S)-3-Ethyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-3-propyl-azetidin-2-yloxy]-benzoic acid tert-butyl ester (1026124-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / acetone / 64 h / Ambient temperature

2: Et₃N, DMAP / CH₂Cl₂ / 19.5 h / 25 - 50 °C

With dmap; sodium hydroxide; triethylamine; In dichloromethane; acetone;

DOI:10.1021/jm00013a021

Reference yield:

Acetic acid (S)-3-ethyl-4-oxo-3-propyl-azetidin-2-yl ester (1026545-73-2) → 4-[(2S,3S)-3-Ethyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-3-propyl-azetidin-2-yloxy]-benzoic acid tert-butyl ester (1026124-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / acetone / 64 h / Ambient temperature

2: Et₃N, DMAP / CH₂Cl₂ / 19.5 h / 25 - 50 °C

With dmap; sodium hydroxide; triethylamine; In dichloromethane; acetone;

DOI:10.1021/jm00013a021

upstream raw materials:

(1R)-1-phenylethyl isocyanate

(3S,4S)-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-3-ethyl-3-propylazetidin-2-one

tert-butyl 4-hydroxybenzoate

Acetic acid (S)-3-ethyl-4-oxo-3-propyl-azetidin-2-yl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1026124-62-8 4-[(2S,3S)-3-Ethyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-3-propyl-azetidin-2-yloxy]-benzoic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send