Methyl 2-<2'-<3'-furanyl>-1'-(N_b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>acetate

Base Information

• Chemical Name: Methyl 2-<2'-<3'-furanyl>-1'-(N_b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>acetate
• CAS No.: 153275-93-5
• Molecular Formula: C₂₅H₂₄N₂O₃
• Molecular Weight: 400.477

Synonyms:Methyl 2-<2'-<3'-furanyl>-1'-(N_b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>acetate

Chemical Property of Methyl 2-<2'-<3'-furanyl>-1'-(N_b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 2-<2'-<3'-furanyl>-1'-(N_b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>acetate

There total 3 articles about Methyl 2-<2'-<3'-furanyl>-1'-(N_b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

furan-3-carboxaldehyde (498-60-2) + 2-<(methoxycarbonyl)methyl>-3-<2-(Nb-benzylamino)ethyl>indole (153000-65-8) → Methyl 2-<2'-<3'-furanyl>-1'-(Nb-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>acetate (153275-93-5)

Guidance literature:

With molecular sieve; boron trifluoride diethyl etherate; In toluene; for 18h; Heating;

DOI:10.1021/jo00078a029

Reference yield:

Methyl 3-<2-b,Nb-bis(phenylmethyl)amino>ethyl>indole-2-ethanoate (146681-76-7) → Methyl 2-<2'-<3'-furanyl>-1'-(Nb-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>acetate (153275-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / H₂ / 10percent Pd/C / acetic acid

2: 44 percent / molecular sieve, BF₃*etherate / toluene / 18 h / Heating

With molecular sieve; boron trifluoride diethyl etherate; hydrogen; palladium on activated charcoal; In acetic acid; toluene;

DOI:10.1021/jo00078a029

Reference yield:

Dimethyl 2-<3-<2-b,Nb-bis(phenylmethyl)amino>ethyl>indolyl>propanedioate (153275-89-9) → Methyl 2-<2'-<3'-furanyl>-1'-(Nb-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>acetate (153275-93-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / LiCl, Et₃N*HCl / N,N-dimethyl-acetamide / 2.5 h / 130 °C

2: 87 percent / H₂ / 10percent Pd/C / acetic acid

3: 44 percent / molecular sieve, BF₃*etherate / toluene / 18 h / Heating

With molecular sieve; boron trifluoride diethyl etherate; hydrogen; triethylamine hydrochloride; lithium chloride; palladium on activated charcoal; In N,N-dimethyl acetamide; acetic acid; toluene;

DOI:10.1021/jo00078a029

upstream raw materials:

furan-3-carboxaldehyde

2-<(methoxycarbonyl)methyl>-3-<2-(N^b-benzylamino)ethyl>indole

Methyl 3-<2-b,N^b-bis(phenylmethyl)amino>ethyl>indole-2-ethanoate

Dimethyl 2-<3-<2-b,N^b-bis(phenylmethyl)amino>ethyl>indolyl>propanedioate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 153275-93-5 Methyl 2-<2'-<3'-furanyl>-1'-(N_b-phenylmethyl)spiro<3H-indole-3,3'-pyrrolidin>-2(1H)-ylidene>acetate

Send

Send

Metric Ton KG G Pound L ML

Send

Send