methyl [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-dimethyl-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-6,10-dioxa-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate

Base Information

Chemical Name:methyl [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-dimethyl-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-6,10-dioxa-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate
CAS No.:1272654-98-4
Molecular Formula:C₄₅H₅₈N₈O₈
Molecular Weight:839.004
Hs Code.:

methyl [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-dimethyl-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-6,10-dioxa-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate

Synonyms:methyl [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-dimethyl-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-6,10-dioxa-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate

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Chemical Property of methyl [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-dimethyl-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-6,10-dioxa-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate

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Technology Process of methyl [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-dimethyl-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-6,10-dioxa-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate

There total 17 articles about methyl [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-dimethyl-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-6,10-dioxa-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1272655-00-1
C₄₅H₅₉N₇O₁₀

: 1272654-98-4
methyl [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-dimethyl-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-6,10-dioxa-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate

Guidance literature:: With ammonium acetate; In 1,4-dioxane; at 110 ℃; Sealed tube;

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1272654-98-4
methyl [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-dimethyl-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-6,10-dioxa-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; HATU / dichloromethane / 0.17 h

1.2: 4 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

3.1: toluene-4-sulfonic acid / toluene / Reflux; Dean stark trap

4.1: water; lithium hydroxide / tetrahydrofuran; tert-butyl alcohol / 2 h / 20 °C

4.2: pH 3

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.05 h

5.2: 2 h / 20 °C

6.1: ammonium acetate / 1,4-dioxane / 110 °C / Sealed tube

With ammonium acetate; water; Dess-Martin periodane; triethylamine; HATU; lithium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1272654-98-4
methyl [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-dimethyl-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-6,10-dioxa-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: HATU; triethylamine

2.1: Dess-Martin periodane

3.1: toluene-4-sulfonic acid

4.1: water; lithium hydroxide / tetrahydrofuran; tert-butyl alcohol / 2 h / 20 °C

5.1: HATU; triethylamine / N,N-dimethyl-formamide / 0.05 h / Inert atmosphere

5.2: 2 h / 20 °C / Inert atmosphere

6.1: ammonium acetate / 1,4-dioxane / 110 °C / Sealed tube; Inert atmosphere

With ammonium acetate; water; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; tert-butyl alcohol;