2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-(4-(trifluoromethoxy)phenyl)pyridine

Base Information

Chemical Name:2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-(4-(trifluoromethoxy)phenyl)pyridine
CAS No.:1340593-96-5
Molecular Formula:C₂₁H₁₂F₇NO₂
Molecular Weight:443.321
Hs Code.:

Synonyms:2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-(4-(trifluoromethoxy)phenyl)pyridine

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Chemical Property of 2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-(4-(trifluoromethoxy)phenyl)pyridine

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Technology Process of 2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-(4-(trifluoromethoxy)phenyl)pyridine

There total 5 articles about 2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-(4-(trifluoromethoxy)phenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 294182-28-8
5-bromo-2-((-2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridine

: 1340593-96-5
2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-(4-(trifluoromethoxy)phenyl)pyridine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 3h; Temperature; Time; Inert atmosphere; Reflux;

Reference yield:

: 1340593-87-4
1-(2,4-difluorophenyl)-2,2-difluoro-2-(5-(4-(trifluoromethoxy)phenyl)pyridin-2-yl)ethanone

: 1774-47-6
trimethylsulfoxonium iodide

: 1340593-96-5
2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-(4-(trifluoromethoxy)phenyl)pyridine

Guidance literature:: trimethylsulfoxonium iodide; With potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide; at 20 - 25 ℃; for 0.5h;

1-(2,4-difluorophenyl)-2,2-difluoro-2-(5-(4-(trifluoromethoxy)phenyl)pyridin-2-yl)ethanone; In tetrahydrofuran; dimethyl sulfoxide; at 0 - 2 ℃; for 1.2125h;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1340593-96-5
2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-(4-(trifluoromethoxy)phenyl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / diethyl ether / 3 h / -70 - 20 °C

3.1: diethyl ether / 2 h / 0 - 20 °C

4.1: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide / 4 h / 20 - 75 °C / Inert atmosphere

With n-butyllithium; copper; sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;