(S)-1-(4-chloro-2-(3-chlorophenylcarbamoyl)phenoxy)-3-methyl-1-oxobutan-2-aminium bromide

Base Information

• Chemical Name: (S)-1-(4-chloro-2-(3-chlorophenylcarbamoyl)phenoxy)-3-methyl-1-oxobutan-2-aminium bromide
• CAS No.: 1206874-32-9
• Molecular Formula: BrH*C₁₈H₁₈Cl₂N₂O₃
• Molecular Weight: 462.17

Synonyms:(S)-1-(4-chloro-2-(3-chlorophenylcarbamoyl)phenoxy)-3-methyl-1-oxobutan-2-aminium bromide

Chemical Property of (S)-1-(4-chloro-2-(3-chlorophenylcarbamoyl)phenoxy)-3-methyl-1-oxobutan-2-aminium bromide

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Technology Process of (S)-1-(4-chloro-2-(3-chlorophenylcarbamoyl)phenoxy)-3-methyl-1-oxobutan-2-aminium bromide

There total 2 articles about (S)-1-(4-chloro-2-(3-chlorophenylcarbamoyl)phenoxy)-3-methyl-1-oxobutan-2-aminium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-4-chloro-2-(3-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)-3-methylbutanoate (1169776-41-3) → (S)-1-(4-chloro-2-(3-chlorophenylcarbamoyl)phenoxy)-3-methyl-1-oxobutan-2-aminium bromide (1206874-32-9)

Guidance literature:

With hydrogen bromide; In acetic acid; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2009.10.084

Reference yield:

tert-butyl (S)-1-((2-(3-chlorophenylcarbamoyl)-4-chlorophenoxy)carbonyl)-2-methylpropylcarbamate (1206874-28-3) → (S)-1-(4-chloro-2-(3-chlorophenylcarbamoyl)phenoxy)-3-methyl-1-oxobutan-2-aminium bromide (1206874-32-9)

Guidance literature:

With hydrogen bromide; In acetic acid; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2009.10.084

Reference yield: 46.0%

(S)-1-(4-chloro-2-(3-chlorophenylcarbamoyl)phenoxy)-3-methyl-1-oxobutan-2-aminium bromide (1206874-32-9) → 2-(5-chloro-2-hydroxyphenyl)-3-(3-chlorophenyl)-5-isopropyl-3,5-dihydro-4H-imidazol-4-one (1206874-42-1) + (S)-5-chloro-N-(1-(3-chlorophenylamino)-3-methyl-1-oxobutan-2-yl)-2-hydroxybenzamide (1206874-37-4)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 0.5h; Mechanism;

DOI:10.1016/j.tetlet.2009.10.084

upstream raw materials:

(S)-4-chloro-2-(3-chlorophenylcarbamoyl)phenyl 2-(benzyloxycarbonylamino)-3-methylbutanoate

tert-butyl (S)-1-((2-(3-chlorophenylcarbamoyl)-4-chlorophenoxy)carbonyl)-2-methylpropylcarbamate

Downstream raw materials:

2-(5-chloro-2-hydroxyphenyl)-3-(3-chlorophenyl)-5-isopropyl-3,5-dihydro-4H-imidazol-4-one

(S)-5-chloro-N-(1-(3-chlorophenylamino)-3-methyl-1-oxobutan-2-yl)-2-hydroxybenzamide

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