dimethyl 1-benzyl-4-(4-fluorophenyl)-2,6-dioxo-3,5-piperidinedicarboxylate

Base Information

Chemical Name:dimethyl 1-benzyl-4-(4-fluorophenyl)-2,6-dioxo-3,5-piperidinedicarboxylate
CAS No.:511284-26-7
Molecular Formula:C₂₂H₂₀FNO₆
Molecular Weight:413.402
Hs Code.:

Synonyms:dimethyl 1-benzyl-4-(4-fluorophenyl)-2,6-dioxo-3,5-piperidinedicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dimethyl 1-benzyl-4-(4-fluorophenyl)-2,6-dioxo-3,5-piperidinedicarboxylate

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Technology Process of dimethyl 1-benzyl-4-(4-fluorophenyl)-2,6-dioxo-3,5-piperidinedicarboxylate

There total 2 articles about dimethyl 1-benzyl-4-(4-fluorophenyl)-2,6-dioxo-3,5-piperidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 17640-15-2
methyl cyanoformate

: 511283-91-3
1-(phenylmethyl)-4-(4-fluorophenyl)piperidin-2,6-dione

: 511284-07-4
(3S,4R)-1-benzyl-4-(4-fluorophenyl)-2,6-dioxopiperidine-3-carboxylic acid methyl ester

: 511284-26-7
dimethyl 1-benzyl-4-(4-fluorophenyl)-2,6-dioxo-3,5-piperidinedicarboxylate

Guidance literature:: 1-(phenylmethyl)-4-(4-fluorophenyl)piperidin-2,6-dione; With (R,S,S,R)-PhCH(Me)N(Li)CH(Ph)CH(Ph)N(Li)CH(Me)Ph; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

methyl cyanoformate; In tetrahydrofuran; hexane; at -78 ℃; for 3h;
DOI:10.1055/s-2002-35588