N⁴-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-(S)-propan-2-yl)cytosine

Base Information

• Chemical Name: N⁴-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-(S)-propan-2-yl)cytosine
• CAS No.: 1443744-42-0
• Molecular Formula: C₄₁H₅₂N₅O₇P
• Molecular Weight: 757.867

Synonyms:N⁴-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-(S)-propan-2-yl)cytosine

Chemical Property of N⁴-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-(S)-propan-2-yl)cytosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-(S)-propan-2-yl)cytosine

There total 4 articles about N⁴-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-(S)-propan-2-yl)cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N4-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-hydroxy-(S)-propan-2-yl)cytosine (1443744-38-4) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → N4-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-(S)-propan-2-yl)cytosine (1443744-42-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1.91667h; Inert atmosphere;

DOI:10.1002/anie.201300795

Reference yield:

1’-O-([4,4’-dimethoxytriphenyl]methyl)-3’-O-(t-butyldiphenylsilyl)-(S)-propan-2-ol → N4-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-(S)-propan-2-yl)cytosine (1443744-42-0)

Guidance literature:

Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 0.5 h / Inert atmosphere; Sonication

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.01 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.92 h / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1002/anie.201300795

Reference yield:

N4-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[t-butyldiphenylsilyl]-(S)-propan-2-yl)cytosine (1443744-34-0) → N4-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-(S)-propan-2-yl)cytosine (1443744-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 1 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.3762/bjoc.10.220

upstream raw materials:

N⁴-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-hydroxy-(S)-propan-2-yl)cytosine

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

N⁴-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[t-butyldiphenylsilyl]-(S)-propan-2-yl)cytosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1443744-42-0 N⁴-isobutyryl-1-(1’-O-[(4,4’-dimethoxytriphenyl)methyl]-3’-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-(S)-propan-2-yl)cytosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send