(R)-N-allyl-N-[(S)-1-phenylethyl]-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-buten-1-amine

Base Information

• Chemical Name: (R)-N-allyl-N-[(S)-1-phenylethyl]-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-buten-1-amine
• CAS No.: 1350716-16-3
• Molecular Formula: C₂₀H₂₉NO₂
• Molecular Weight: 315.456

Synonyms:(R)-N-allyl-N-[(S)-1-phenylethyl]-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-buten-1-amine

Chemical Property of (R)-N-allyl-N-[(S)-1-phenylethyl]-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-buten-1-amine

Chemical Property:

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Technology Process of (R)-N-allyl-N-[(S)-1-phenylethyl]-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-buten-1-amine

There total 2 articles about (R)-N-allyl-N-[(S)-1-phenylethyl]-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-buten-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(R)-N-[(S)-1-phenylethyl]-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-buten-1-amine (1350716-23-2) + allyl bromide (106-95-6) → (R)-N-allyl-N-[(S)-1-phenylethyl]-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-buten-1-amine (1350716-16-3)

Guidance literature:

With sodium hydrogencarbonate; lithium iodide; In acetonitrile; for 36h; Reflux;

DOI:10.1039/c1ob06216f

Reference yield:

C14H19NO2 → (R)-N-allyl-N-[(S)-1-phenylethyl]-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-buten-1-amine (1350716-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 12 h / -20 °C / Inert atmosphere

2: sodium hydrogencarbonate; lithium iodide / acetonitrile / 36 h / Reflux

With sodium hydrogencarbonate; lithium iodide; In diethyl ether; acetonitrile;

DOI:10.1039/c1ob06216f

Reference yield: 87.0%

(R)-N-allyl-N-[(S)-1-phenylethyl]-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-buten-1-amine (1350716-16-3) → (R)-N-[(S)-1-phenylethyl]-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-1,2,3,6-tetrahydropyridine (1350716-17-4)

Guidance literature:

With Grubbs catalyst first generation; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1039/c1ob06216f

upstream raw materials:

(R)-N-[(S)-1-phenylethyl]-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-buten-1-amine

allyl bromide

Downstream raw materials:

(R)-N-[(S)-1-phenylethyl]-2-[(S)-1-hydroxy-3-buten-2-yl]-1,2,3,6-tetrahydropyridine

(R)-N-[(S)-1-phenylethyl]-2-[(R)-1-hydroxypropyl]-1,2,3,6-tetrahydropyridine

(R)-N-[(S)-1-phenylethyl]-2-[(R)-2-phenyl-1-hydroxyethyl]-1,2,3,6-tetrahydropyridine

(R)-N-[(S)-1-phenylethyl]-2-[(R)-1-hydroxy-3-methylbutyl]-1,2,3,6-tetrahydropyridine

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