(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)tetrahydrofuran-2-carboxamide

Base Information

Chemical Name:(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)tetrahydrofuran-2-carboxamide
CAS No.:1342803-59-1
Molecular Formula:C₃₁H₃₆F₃N₃O₂S
Molecular Weight:571.707
Hs Code.:

Synonyms:(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)tetrahydrofuran-2-carboxamide

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Chemical Property of (S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)tetrahydrofuran-2-carboxamide

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Technology Process of (S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)tetrahydrofuran-2-carboxamide

There total 14 articles about (S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)tetrahydrofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1342804-08-3
(3R,4R)-benzyl 3-(((S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)tetrahydroruran-2-carboxamido)methyl)-4-fluoropyrrolidine-1-carboxylate

: 1342803-59-1
(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)tetrahydrofuran-2-carboxamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 87392-07-2
(S)-tetrahydro-2-furoic acid

: 1342803-59-1
(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)tetrahydrofuran-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 0.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / Inert atmosphere

With thionyl chloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 1342803-59-1
(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)tetrahydrofuran-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: copper(ll) bromide / ethyl acetate; chloroform / 6 h / Reflux

2.1: methanol / Reflux

2.2: 20 °C

3.1: Dess-Martin periodane / dichloromethane / 20 °C

4.1: titanium(IV) tetraethanolate / tetrahydrofuran / 4 h / 20 °C

5.1: pentane; tetrahydrofuran / 3 h / -78 °C

5.2: -78 °C

5.3: -78 °C

6.1: hydrogenchloride; methanol / 1,4-dioxane; tetrahydrofuran / 1 h / 20 °C

7.1: sodium tris(acetoxy)borohydride / dichloromethane / 0.5 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; methanol; titanium(IV) tetraethanolate; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; ethyl acetate; pentane;