N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys-N-Me-L-Cys(Me)]-OH

Base Information

Chemical Name:N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys-N-Me-L-Cys(Me)]-OH
CAS No.:270587-99-0
Molecular Formula:C₄₉H₆₈N₈O₁₅S₆
Molecular Weight:1201.52
Hs Code.:

Synonyms:N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys-N-Me-L-Cys(Me)]-OH

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys-N-Me-L-Cys(Me)]-OH

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Technology Process of N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys-N-Me-L-Cys(Me)]-OH

There total 16 articles about N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys-N-Me-L-Cys(Me)]-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 328553-28-2
C₅₅H₈₀N₁₀O₁₇S₆

: 270587-99-0
N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys-N-Me-L-Cys(Me)]-OH

Guidance literature:: With iodine; In methanol; dichloromethane; at 25 ℃; for 2h;
DOI:10.1021/ja0001660

Reference yield:

: 66877-08-5
H-NMe-Cys(Me)-OH

: 270587-99-0
N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys-N-Me-L-Cys(Me)]-OH

Guidance literature:: Multi-step reaction with 12 steps

1.1: H₂O / 12 h / 25 °C / pH 8

2.1: 91 percent / benzene; methanol / 0 °C

3.1: 91 percent / HCl / ethyl acetate / 0.5 h / 25 °C

4.1: HOAt; EDCI / CH₂Cl₂ / 0.25 h / 0 °C

4.2: 78 percent / CH₂Cl₂ / 12 h

5.1: 100 percent / HCl / ethyl acetate / 0.5 h / 25 °C

6.1: 68 percent / HOAt; EDCI; NaHCO₃ / CH₂Cl₂ / 12 h / 0 °C

7.1: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 1.5 h / 25 °C

8.1: HOAt; EDCI / CH₂Cl₂ / 15 h / -20 °C

8.2: 49 percent / CH₂Cl₂ / 4 h

9.1: 100 percent / Zn; 90percent aq. AcOH / 2 h / 0 °C

10.1: 83 percent / HOAt; EDCI / CH₂Cl₂ / 6 h / 0 °C

11.1: Zn; 90percent aq. AcOH / 2 h / 0 °C

12.1: I₂ / CH₂Cl₂; methanol / 2 h / 25 °C

With hydrogenchloride; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; iodine; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; benzene;
DOI:10.1021/ja003602r

Reference yield:

: 270587-81-0
Boc-N,S-dimethylcysteine

: 270587-99-0
N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys-N-Me-L-Cys(Me)]-OH

Guidance literature:: Multi-step reaction with 11 steps

1.1: 91 percent / benzene; methanol / 0 °C

2.1: 91 percent / HCl / ethyl acetate / 0.5 h / 25 °C

3.1: HOAt; EDCI / CH₂Cl₂ / 0.25 h / 0 °C

3.2: 78 percent / CH₂Cl₂ / 12 h

4.1: 100 percent / HCl / ethyl acetate / 0.5 h / 25 °C

5.1: 68 percent / HOAt; EDCI; NaHCO₃ / CH₂Cl₂ / 12 h / 0 °C

6.1: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 1.5 h / 25 °C

7.1: HOAt; EDCI / CH₂Cl₂ / 15 h / -20 °C

7.2: 49 percent / CH₂Cl₂ / 4 h

8.1: 100 percent / Zn; 90percent aq. AcOH / 2 h / 0 °C

9.1: 83 percent / HOAt; EDCI / CH₂Cl₂ / 6 h / 0 °C

10.1: Zn; 90percent aq. AcOH / 2 h / 0 °C

11.1: I₂ / CH₂Cl₂; methanol / 2 h / 25 °C

With hydrogenchloride; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; iodine; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; benzene;
DOI:10.1021/ja003602r