cis-3-azido-1-(4-methoxyphenyl)-2-oxo-4-(2-phenylethenyl)azetidine

Base Information

• Chemical Name: cis-3-azido-1-(4-methoxyphenyl)-2-oxo-4-(2-phenylethenyl)azetidine
• CAS No.: 80542-41-2
• Molecular Formula: C₁₈H₁₆N₄O₂
• Molecular Weight: 320.351
• Mol file: 80542-41-2.mol

Synonyms:cis-3-azido-1-(4-methoxyphenyl)-2-oxo-4-(2-phenylethenyl)azetidine

Chemical Property of cis-3-azido-1-(4-methoxyphenyl)-2-oxo-4-(2-phenylethenyl)azetidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-3-azido-1-(4-methoxyphenyl)-2-oxo-4-(2-phenylethenyl)azetidine

There total 6 articles about cis-3-azido-1-(4-methoxyphenyl)-2-oxo-4-(2-phenylethenyl)azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-(3-phenyl-2-propenylidene)-4-methoxyaniline (123525-44-0) + azidoacetic acid potassium salt → cis-3-azido-1-(4-methoxyphenyl)-2-oxo-4-(2-phenylethenyl)azetidine (80542-41-2)

Guidance literature:

With 1,3,5-trichloro-2,4,6-triazine; triethylamine; In dichloromethane; Ambient temperature;

Reference yield: 60.0%

2-azidoacetic acid (18523-48-3) + N-cinnamylidene-p-anisidine (80542-40-1) → cis-3-azido-1-(4-methoxyphenyl)-2-oxo-4-(2-phenylethenyl)azetidine (80542-41-2)

Guidance literature:

With triethylamine; trifluoroacetic anhydride; In dichloromethane; 1.) 0 deg C, 2.) 0 deg C, 1 h, 3.) room temperature, 12 h;

DOI:10.1021/jo00135a016

Reference yield:

(E)-3-phenylpropenal (14371-10-9) → cis-3-azido-1-(4-methoxyphenyl)-2-oxo-4-(2-phenylethenyl)azetidine (80542-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / MgSO₄ / CH₂Cl₂ / 2 h / 0 °C

2: 60 percent / 1.) Et₃N, 2.) trifluoroacetic anhydride / CH₂Cl₂ / 1.) 0 deg C, 2.) 0 deg C, 1 h, 3.) room temperature, 12 h

With magnesium sulfate; triethylamine; trifluoroacetic anhydride; In dichloromethane;

DOI:10.1021/jo00135a016

upstream raw materials:

2-azidoacetic acid

N-cinnamylidene-p-anisidine

N-(3-phenyl-2-propenylidene)-4-methoxyaniline

(E)-3-phenylpropenal

Downstream raw materials:

cis-3-azido-2-oxo-4-(2-phenylethenyl)-1-azetidine

cis-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-4-(2-phenylethenyl)-1-azetidine