Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h
1.2: 18.25 h / 22 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / dichloromethane; toluene / 3.33 h / -78 °C
2.2: 0.5 h
3.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h
3.2: 18.08 h / 22 °C / Inert atmosphere
4.1: toluene-4-sulfonic acid / tetrahydrofuran; ethyl acetate / 1 h / 20 °C
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere
5.2: 0.42 h / -78 °C / Inert atmosphere
6.1: sodium hydrogencarbonate; N-Bromosuccinimide / tetrahydrofuran / 2.25 h / -20 - 0 °C
7.1: isopropyl alcohol / 48 h / 65 °C
With
N-Bromosuccinimide; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;