2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimidazo[1,2-b]pyridazine

Base Information

Chemical Name:2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimidazo[1,2-b]pyridazine
CAS No.:1476848-33-5
Molecular Formula:C₂₃H₁₉N₃O₃
Molecular Weight:385.422
Hs Code.:

Synonyms:2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimidazo[1,2-b]pyridazine

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Chemical Property of 2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimidazo[1,2-b]pyridazine

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Technology Process of 2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimidazo[1,2-b]pyridazine

There total 10 articles about 2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 18591-87-2,18591-82-7
3-amino-6-methylpyridazine

: 1476847-52-5
1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

: 1476848-33-5
2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimidazo[1,2-b]pyridazine

Guidance literature:: In isopropyl alcohol; at 65 ℃; for 48h;

Reference yield:

: 18591-87-2,18591-82-7
3-amino-6-methylpyridazine

: ethyl acetate dichloromethane

: 1476847-52-5
1-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-2-bromoethanone

: 67-63-0,8013-70-5
isopropyl alcohol

: 1476848-33-5
2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimidazo[1,2-b]pyridazine

Guidance literature:: In ethyl acetate;

Reference yield:

: 532394-23-3
5-hydroxy-7-methoxy-2,2-dimethyl-benzo[1,3]dioxin-4-one

: 1476848-33-5
2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h

1.2: 18.25 h / 22 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 3.33 h / -78 °C

2.2: 0.5 h

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h

3.2: 18.08 h / 22 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / tetrahydrofuran; ethyl acetate / 1 h / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere

5.2: 0.42 h / -78 °C / Inert atmosphere

6.1: sodium hydrogencarbonate; N-Bromosuccinimide / tetrahydrofuran / 2.25 h / -20 - 0 °C

7.1: isopropyl alcohol / 48 h / 65 °C

With N-Bromosuccinimide; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;