[3-(2-Chloro-ethyl)-2,4-dioxo-2-phenylthiocarbamoyl-3,4-dihydro-2H-2λ⁵-benzo[1,3,2]diazaphosphinin-1-yl]-acetic acid ethyl ester

Base Information

• Chemical Name: [3-(2-Chloro-ethyl)-2,4-dioxo-2-phenylthiocarbamoyl-3,4-dihydro-2H-2λ⁵-benzo[1,3,2]diazaphosphinin-1-yl]-acetic acid ethyl ester
• CAS No.: 125405-42-7
• Molecular Formula: C₂₀H₂₁ClN₃O₄PS
• Molecular Weight: 465.897

Synonyms:[3-(2-Chloro-ethyl)-2,4-dioxo-2-phenylthiocarbamoyl-3,4-dihydro-2H-2λ⁵-benzo[1,3,2]diazaphosphinin-1-yl]-acetic acid ethyl ester

Chemical Property of [3-(2-Chloro-ethyl)-2,4-dioxo-2-phenylthiocarbamoyl-3,4-dihydro-2H-2λ⁵-benzo[1,3,2]diazaphosphinin-1-yl]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of [3-(2-Chloro-ethyl)-2,4-dioxo-2-phenylthiocarbamoyl-3,4-dihydro-2H-2λ⁵-benzo[1,3,2]diazaphosphinin-1-yl]-acetic acid ethyl ester

There total 3 articles about [3-(2-Chloro-ethyl)-2,4-dioxo-2-phenylthiocarbamoyl-3,4-dihydro-2H-2λ⁵-benzo[1,3,2]diazaphosphinin-1-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

[3-(2-Chloro-ethyl)-2,4-dioxo-3,4-dihydro-2H-2λ5-benzo[1,3,2]diazaphosphinin-1-yl]-acetic acid ethyl ester (125405-40-5) + phenyl isothiocyanate (103-72-0) → [3-(2-Chloro-ethyl)-2,4-dioxo-2-phenylthiocarbamoyl-3,4-dihydro-2H-2λ5-benzo[1,3,2]diazaphosphinin-1-yl]-acetic acid ethyl ester (125405-42-7)

Guidance literature:

With triethylamine; In benzene; at 60 ℃; for 5h;

DOI:10.1055/s-1989-27336

Reference yield:

1-Ethoxycarbonylmethyl-2H-3,1-benzoxazine-2,4(1H)-dione (57384-71-1) → [3-(2-Chloro-ethyl)-2,4-dioxo-2-phenylthiocarbamoyl-3,4-dihydro-2H-2λ5-benzo[1,3,2]diazaphosphinin-1-yl]-acetic acid ethyl ester (125405-42-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / Et₃N / dioxane; H₂O / 3 h / 50 °C

2: 1.) PCl₃, 2.) 5percent aq. NaHCO₃ / 1.) benzene, reflux, 5 h, 2.) 0 deg C

3: 1.) NaH / 1.) THF, 0 deg C, 2.) room temp, 4 h

With sodium hydride; sodium hydrogencarbonate; triethylamine; phosphorus trichloride; In 1,4-dioxane; water;

DOI:10.1055/s-1989-27336

Reference yield:

2-(2-ethoxycarbonylmethylphenylamino)-4,5-dihydrooxazole (125405-37-0) → [3-(2-Chloro-ethyl)-2,4-dioxo-2-phenylthiocarbamoyl-3,4-dihydro-2H-2λ5-benzo[1,3,2]diazaphosphinin-1-yl]-acetic acid ethyl ester (125405-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) PCl₃, 2.) 5percent aq. NaHCO₃ / 1.) benzene, reflux, 5 h, 2.) 0 deg C

2: 1.) NaH / 1.) THF, 0 deg C, 2.) room temp, 4 h

With sodium hydride; sodium hydrogencarbonate; phosphorus trichloride;

DOI:10.1055/s-1989-27336

upstream raw materials:

[3-(2-Chloro-ethyl)-2,4-dioxo-3,4-dihydro-2H-2λ⁵-benzo[1,3,2]diazaphosphinin-1-yl]-acetic acid ethyl ester

phenyl isothiocyanate

1-Ethoxycarbonylmethyl-2H-3,1-benzoxazine-2,4(1H)-dione

2-(2-ethoxycarbonylmethylphenylamino)-4,5-dihydrooxazole

Downstream raw materials:

{9a,10-Dioxo-1-[(Z)-phenylimino]-1,3,4,9a-tetrahydro-10H-2-thia-4a,9-diaza-9aλ⁵-phospha-anthracen-9-yl}-acetic acid ethyl ester

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