N-[3-(bromomethyl)phenyl]-N-methyl-2-(2-oxo-5-phenyl-1,3-benzoxazol-3(2H)-yl)acetamide

Base Information

Chemical Name:N-[3-(bromomethyl)phenyl]-N-methyl-2-(2-oxo-5-phenyl-1,3-benzoxazol-3(2H)-yl)acetamide
CAS No.:1396795-71-3
Molecular Formula:C₂₃H₁₉BrN₂O₃
Molecular Weight:451.319
Hs Code.:

Synonyms:N-[3-(bromomethyl)phenyl]-N-methyl-2-(2-oxo-5-phenyl-1,3-benzoxazol-3(2H)-yl)acetamide

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Chemical Property of N-[3-(bromomethyl)phenyl]-N-methyl-2-(2-oxo-5-phenyl-1,3-benzoxazol-3(2H)-yl)acetamide

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Technology Process of N-[3-(bromomethyl)phenyl]-N-methyl-2-(2-oxo-5-phenyl-1,3-benzoxazol-3(2H)-yl)acetamide

There total 4 articles about N-[3-(bromomethyl)phenyl]-N-methyl-2-(2-oxo-5-phenyl-1,3-benzoxazol-3(2H)-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: N-[3-(hydroxymethyl)phenyl]-N-methyl-2-(2-oxo-5-phenyl-1,3-benzoxazol-3(2H)-yl)acetamide

: 1396795-71-3
N-[3-(bromomethyl)phenyl]-N-methyl-2-(2-oxo-5-phenyl-1,3-benzoxazol-3(2H)-yl)acetamide

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In acetonitrile; at 20 ℃; for 1h; Cooling with ice;
DOI:10.1016/j.bmc.2012.07.023

Reference yield:

: 1396795-65-5
tert-butyl (2-oxo-5-phenyl-1,3-benzoxazol-3(2H)-yl)acetate

: 1396795-71-3
N-[3-(bromomethyl)phenyl]-N-methyl-2-(2-oxo-5-phenyl-1,3-benzoxazol-3(2H)-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / acetic acid; 1,4-dioxane / 4 h / 50 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

3: carbon tetrabromide; triphenylphosphine / acetonitrile / 1 h / 20 °C / Cooling with ice

With hydrogenchloride; carbon tetrabromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2012.07.023

Reference yield:

: 1134-36-7
2-amino-4-phenylphenol

: 1396795-71-3
N-[3-(bromomethyl)phenyl]-N-methyl-2-(2-oxo-5-phenyl-1,3-benzoxazol-3(2H)-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 2 h / Reflux

2: potassium carbonate / acetone / 24 h / 20 °C / Cooling with ice

3: hydrogenchloride / acetic acid; 1,4-dioxane / 4 h / 50 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

5: carbon tetrabromide; triphenylphosphine / acetonitrile / 1 h / 20 °C / Cooling with ice

With hydrogenchloride; carbon tetrabromide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; acetic acid; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmc.2012.07.023