(S)-2-(3-(2-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoic acid

Base Information

• Chemical Name: (S)-2-(3-(2-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoic acid
• CAS No.: 858033-45-1
• Molecular Formula: C₁₆H₂₁FN₂O₃
• Molecular Weight: 308.353

Synonyms:(S)-2-(3-(2-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoic acid

Chemical Property of (S)-2-(3-(2-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoic acid

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Technology Process of (S)-2-(3-(2-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoic acid

There total 1 articles about (S)-2-(3-(2-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H29FN2O3 (858033-44-0) → (S)-2-(3-(2-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoic acid (858033-45-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm900044w

Reference yield: 61.0%

(S)-2-(3-(2-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoic acid (858033-45-1) + methyl (S)-1-((2S,4S,5S)-5-amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate (854754-04-4) → methyl (S)-1-((2S,4S,5S)-4-hydroxy-5-((S)-2-(3-(2-fluorobenzyl)-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanamido)-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; at 25 ℃; for 16h;

upstream raw materials:

C₂₀H₂₉FN₂O₃

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