(2R,3S)-2-Chloromethyl-3-propyl-oxirane

Base Information

Chemical Name:(2R,3S)-2-Chloromethyl-3-propyl-oxirane
CAS No.:185377-65-5
Molecular Formula:C₆H₁₁ClO
Molecular Weight:134.606
Hs Code.:

Synonyms:(2R,3S)-2-Chloromethyl-3-propyl-oxirane

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Chemical Property of (2R,3S)-2-Chloromethyl-3-propyl-oxirane

Chemical Property:

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Technology Process of (2R,3S)-2-Chloromethyl-3-propyl-oxirane

There total 1 articles about (2R,3S)-2-Chloromethyl-3-propyl-oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 89321-71-1
(2S,3S)-3-propyl-2-oxiranemethanol

: 185377-65-5
(2R,3S)-2-Chloromethyl-3-propyl-oxirane

Guidance literature:: With tetrachloromethane; sodium hydrogencarbonate; triphenylphosphine; for 3h; Heating;
DOI:10.1016/0040-4039(96)01960-0

Reference yield:

: 185377-65-5
(2R,3S)-2-Chloromethyl-3-propyl-oxirane

: C₃₅H₃₉Cl₆NO₇

Guidance literature:: Multi-step reaction with 12 steps

1: 70 percent / LiNH₂ / tetrahydrofuran / 6 h / -30 °C

2: 65 percent / NaNH₂, diaminopropane / 2 h / 80 °C

3: 1.) EtMgBr, 2.) CuCl / 1.) THF, 2.) THF

4: 86 percent / H₂ / Pd/CaCO₃ / methanol / 3 h

5: NEt₃ / CH₂Cl₂ / 3 h / 0 °C

6: 8 h / 80 °C

7: 75 percent / NEt₃ / CH₂Cl₂ / 3 h / Ambient temperature

8: 95 percent / DMAP / CH₂Cl₂ / 1 h / Ambient temperature

9: 82 percent / PPTS / ethanol / 4 h / Heating

10: PCC, celite / CH₂Cl₂ / 3 h

11: Ag₂O, NaOH, H₂O / ethanol / 4 h / Ambient temperature

12: NEt₃ / tetrahydrofuran / 2 h / Ambient temperature

With dmap; sodium hydroxide; lithium amide; Celite; ethylmagnesium bromide; water; hydrogen; pyridinium p-toluenesulfonate; sodium amide; Trimethylenediamine; triethylamine; pyridinium chlorochromate; copper(l) chloride; silver(l) oxide; Lindlar's catalyst; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/0040-4039(96)01960-0

Reference yield:

: 185377-65-5
(2R,3S)-2-Chloromethyl-3-propyl-oxirane

: 147363-83-5
(7Z,10Z)-(R)-5-Propyl-1-oxa-4-aza-cyclopentadeca-7,10-dien-15-one

Guidance literature:: Multi-step reaction with 14 steps

1: 70 percent / LiNH₂ / tetrahydrofuran / 6 h / -30 °C

2: 65 percent / NaNH₂, diaminopropane / 2 h / 80 °C

3: 1.) EtMgBr, 2.) CuCl / 1.) THF, 2.) THF

4: 86 percent / H₂ / Pd/CaCO₃ / methanol / 3 h

5: NEt₃ / CH₂Cl₂ / 3 h / 0 °C

6: 8 h / 80 °C

7: 75 percent / NEt₃ / CH₂Cl₂ / 3 h / Ambient temperature

8: 95 percent / DMAP / CH₂Cl₂ / 1 h / Ambient temperature

9: 82 percent / PPTS / ethanol / 4 h / Heating

10: PCC, celite / CH₂Cl₂ / 3 h

11: Ag₂O, NaOH, H₂O / ethanol / 4 h / Ambient temperature

12: NEt₃ / tetrahydrofuran / 2 h / Ambient temperature

13: 78 percent / DMAP / toluene / 12 h / 90 °C

14: 90 percent / TFA / 0.25 h / Ambient temperature

With dmap; sodium hydroxide; lithium amide; Celite; ethylmagnesium bromide; water; hydrogen; pyridinium p-toluenesulfonate; sodium amide; Trimethylenediamine; triethylamine; pyridinium chlorochromate; trifluoroacetic acid; copper(l) chloride; silver(l) oxide; Lindlar's catalyst; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/0040-4039(96)01960-0