5-bromo-2-(((2S,4R)-4-(tert-butoxycarbonylamino)-1-((2-(trimethylsilyl)ethoxy)carbonyl)pyrrolidin-2-yl)-methoxy)benzoic acid

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Chemical Name:5-bromo-2-(((2S,4R)-4-(tert-butoxycarbonylamino)-1-((2-(trimethylsilyl)ethoxy)carbonyl)pyrrolidin-2-yl)-methoxy)benzoic acid
CAS No.:1266099-83-5
Molecular Formula:C₂₃H₃₅BrN₂O₇Si
Molecular Weight:559.53
Hs Code.:

Synonyms:5-bromo-2-(((2S,4R)-4-(tert-butoxycarbonylamino)-1-((2-(trimethylsilyl)ethoxy)carbonyl)pyrrolidin-2-yl)-methoxy)benzoic acid

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Chemical Property of 5-bromo-2-(((2S,4R)-4-(tert-butoxycarbonylamino)-1-((2-(trimethylsilyl)ethoxy)carbonyl)pyrrolidin-2-yl)-methoxy)benzoic acid

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Technology Process of 5-bromo-2-(((2S,4R)-4-(tert-butoxycarbonylamino)-1-((2-(trimethylsilyl)ethoxy)carbonyl)pyrrolidin-2-yl)-methoxy)benzoic acid

There total 3 articles about 5-bromo-2-(((2S,4R)-4-(tert-butoxycarbonylamino)-1-((2-(trimethylsilyl)ethoxy)carbonyl)pyrrolidin-2-yl)-methoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1266099-82-4
C₂₄H₃₇BrN₂O₇Si

: 1266099-83-5
5-bromo-2-(((2S,4R)-4-(tert-butoxycarbonylamino)-1-((2-(trimethylsilyl)ethoxy)carbonyl)pyrrolidin-2-yl)-methoxy)benzoic acid

Guidance literature:: C₂₄H₃₇BrN₂O₇Si; With water; lithium hydroxide; In tetrahydrofuran; at 50 ℃; for 15h;

With hydrogenchloride; In water;

Reference yield:

: 1264243-41-5,1070295-74-7
tert-butyl ((3R,5S)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamate

: 1266099-83-5
5-bromo-2-(((2S,4R)-4-(tert-butoxycarbonylamino)-1-((2-(trimethylsilyl)ethoxy)carbonyl)pyrrolidin-2-yl)-methoxy)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane

2: triphenylphosphine; diethylazodicarboxylate / toluene; benzene / 16 h / 0 - 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 15 h / 50 °C

With water; triethylamine; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; benzene; 2: Mitsunobu reaction;

Reference yield:

: 80149-80-0
2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate

: 1266099-83-5
5-bromo-2-(((2S,4R)-4-(tert-butoxycarbonylamino)-1-((2-(trimethylsilyl)ethoxy)carbonyl)pyrrolidin-2-yl)-methoxy)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane

2: triphenylphosphine; diethylazodicarboxylate / toluene; benzene / 16 h / 0 - 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 15 h / 50 °C

With water; triethylamine; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; benzene; 2: Mitsunobu reaction;