C₁₀H₁₂FNO₂

Base Information

Chemical Name:C₁₀H₁₂FNO₂
CAS No.:199585-10-9
Molecular Formula:C₁₀H₁₂FNO₂
Molecular Weight:197.209
Hs Code.:

C<sub>10</sub>H<sub>12</sub>FNO<sub>2</sub>

Synonyms:C₁₀H₁₂FNO₂

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Chemical Property of C₁₀H₁₂FNO₂

Chemical Property:

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Technology Process of C₁₀H₁₂FNO₂

There total 1 articles about C₁₀H₁₂FNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 371-41-5
4-Fluorophenol

: 1795-48-8
Isopropyl isocyanate

: 199585-10-9
C₁₀H₁₂FNO₂

Guidance literature:: With dmap; In tetrahydrofuran; Heating;
DOI:10.1055/s-2007-985565

Reference yield: 76.0%

: 199585-10-9
C₁₀H₁₂FNO₂

: C₁₀H₁₁FINO₂

Guidance literature:: C₁₀H₁₂FNO₂; With N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate; In diethyl ether; at 0 - 25 ℃; for 0.5h;

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; at -78 ℃; for 1h;

With iodine; In tetrahydrofuran; diethyl ether; at -78 ℃; for 2h; Further stages.;
DOI:10.1055/s-2007-985565

Reference yield:

: 199585-10-9
C₁₀H₁₂FNO₂

: 4-fluoro-2-iodophenyl triflate

Guidance literature:: Multi-step reaction with 2 steps

1.1: TMSOTf; TMEDA / diethyl ether / 0.5 h / 0 - 25 °C

1.2: TMEDA; n-BuLi / diethyl ether / 1 h / -78 °C

1.3: 76 percent / I₂ / diethyl ether; tetrahydrofuran / 2 h / -78 °C

2.1: 92 percent / DIPEA / CH₂Cl₂ / -78 - 25 °C

With N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1055/s-2007-985565