2-(benzyloxy)-1,1′-biphenyl

Base Information

• Chemical Name: 2-(benzyloxy)-1,1′-biphenyl
• CAS No.: 102806-25-7
• Molecular Formula: C₁₉H₁₆O
• Molecular Weight: 260.335
• Mol file: 102806-25-7.mol

Synonyms:2-(benzyloxy)-1,1′-biphenyl

Chemical Property of 2-(benzyloxy)-1,1′-biphenyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzyloxy)-1,1′-biphenyl

There total 10 articles about 2-(benzyloxy)-1,1′-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate (260783-80-0) + 2-Phenylphenol (90-43-7,287950-96-3) → 2-(benzyloxy)-1,1′-biphenyl (102806-25-7)

Guidance literature:

With 18-crown-6 ether; potassium tert-butylate; In toluene; at 120 ℃; for 3h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.0c02992

Reference yield: 87.0%

2'-(benzyloxy)-(1,1'-biphenyl)-2-yl trifluoromethanesulfonate → 2-(benzyloxy)-1,1′-biphenyl (102806-25-7)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; formic acid; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 120 ℃; for 15h; Glovebox; Sealed tube; Inert atmosphere;

DOI:10.1055/a-1337-5153

Reference yield: 72.0%

phenylacetic acid N-hydroxysuccinimide ester (63591-85-5) + 2-Phenylphenol (90-43-7,287950-96-3) → 2-(benzyloxy)-1,1′-biphenyl (102806-25-7)

Guidance literature:

With tetrakis(acetonitrile)copper(I) trifluoromethanesulfonate; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N-isopropyl-N,2-dimethylpropan-2-amine; In dichloromethane; at 0 - 20 ℃; for 20h; Irradiation; Sealed tube;

DOI:10.1002/anie.201808024

upstream raw materials:

benzyl chloride

2-Phenylphenol

phenylacetic acid N-hydroxysuccinimide ester

phenylacetic acid

Refernces

• 1、 Dey, Aniruddha,Sasmal, Sheuli,Seth, Kapileswar,Lahiri, Goutam Kumar,Maiti, Debabrata. "Nickel-Catalyzed Deamidative Step-Down Reduction of Amides to Aromatic Hydrocarbons". . p. 433 - 437. Retrieved 2017.
• 2、 Liu, Wenbo,Li, Jianbin,Querard, Pierre,Li, Chao-Jun. "Transition-Metal-Free C-C, C-O, and C-N Cross-Couplings Enabled by Light". . p. 6755 - 6764. Retrieved 2019/05/06.