4-((2S,4S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole

Base Information

Chemical Name:4-((2S,4S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole
CAS No.:879872-49-8
Molecular Formula:C₄₁H₅₁NO₇Si
Molecular Weight:697.944
Hs Code.:

4-((2S,4S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole

Synonyms:4-((2S,4S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole

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Chemical Property of 4-((2S,4S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole

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Technology Process of 4-((2S,4S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole

There total 4 articles about 4-((2S,4S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,6R)-2-((S)-2,4-Bis-trimethylsilanyloxy-butyl)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran

: 224578-16-9
2-(4-Methoxy-benzyloxymethyl)-oxazole-4-carbaldehyde

: 879872-49-8
4-((2S,4S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole

Guidance literature:: (2R,6R)-2-((S)-2,4-Bis-trimethylsilanyloxy-butyl)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran; 2-(4-Methoxy-benzyloxymethyl)-oxazole-4-carbaldehyde; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 15h;

With triethylamine; In dichloromethane; at -78 - 0 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: (2R,6R)-2-((S)-2,4-Bis-trimethylsilanyloxy-butyl)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran

: 224578-16-9
2-(4-Methoxy-benzyloxymethyl)-oxazole-4-carbaldehyde

: 879872-49-8
4-((2S,4S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole

: 4-((2R,4S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole

Guidance literature:: (2R,6R)-2-((S)-2,4-Bis-trimethylsilanyloxy-butyl)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran; 2-(4-Methoxy-benzyloxymethyl)-oxazole-4-carbaldehyde; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃;

With triethylamine; In dichloromethane; at -78 ℃;
DOI:10.1021/ol060014v

Reference yield:

: 879872-48-7
(S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-yl}-butane-1,3-diol

: 879872-49-8
4-((2S,4S)-4-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / -78 - 20 °C

2.1: trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 0 °C

2.2: triethylamine / CH₂Cl₂ / -78 °C

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane;
DOI:10.1021/ol060014v