2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl chloride

Base Information

• Chemical Name: 2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl chloride
• CAS No.: 144125-65-5
• Molecular Formula: C₂₆H₁₈Cl₄O₇
• Molecular Weight: 584.237
• Mol file: 144125-65-5.mol

Synonyms:2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl chloride

Chemical Property of 2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl chloride

There total 2 articles about 2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.4%

1-O-acetyl-2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranose (144084-01-5) → 2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl chloride (144125-65-5)

Guidance literature:

With hydrogenchloride; In dichloromethane;

DOI:10.1021/jm00102a006

Reference yield:

methyl 2,3,5-tris-O-(p-chlorobenzoyl)-D-ribofuranoside → 2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl chloride (144125-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.3 percent / conc. H₂SO₄ / acetic acid / 2 h / Ambient temperature

2: 85.4 percent / HCl / CH₂Cl₂

With hydrogenchloride; sulfuric acid; In dichloromethane; acetic acid;

DOI:10.1021/jm00102a006

Reference yield: 52.3%

2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl chloride (144125-65-5) + 6-amino-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine (203180-01-2) → C32H23Cl3IN5O8

Guidance literature:

6-amino-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine; With potassium hydroxide; In methanol; at 20 ℃; for 0.0166667h;

2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl chloride; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 24h; Inert atmosphere;

upstream raw materials:

1-O-acetyl-2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranose

Downstream raw materials:

C₃₂H₂₁Cl₃N₄O₉

4-nitro-1-<2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl>benzotriazole

4-nitro-1-<2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl>benzimidazole

Refernces