1-[4-((5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-17-pentafluoroethyl-5',5',13-trimethyl-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl)benzyl]-3-ethyl urea

Base Information

Chemical Name:1-[4-((5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-17-pentafluoroethyl-5',5',13-trimethyl-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl)benzyl]-3-ethyl urea
CAS No.:1262049-53-5
Molecular Formula:C₃₅H₄₇F₅N₂O₅
Molecular Weight:670.761
Hs Code.:

1-[4-((5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-17-pentafluoroethyl-5',5',13-trimethyl-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl)benzyl]-3-ethyl urea

Synonyms:1-[4-((5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-17-pentafluoroethyl-5',5',13-trimethyl-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl)benzyl]-3-ethyl urea

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Chemical Property of 1-[4-((5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-17-pentafluoroethyl-5',5',13-trimethyl-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl)benzyl]-3-ethyl urea

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Technology Process of 1-[4-((5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-17-pentafluoroethyl-5',5',13-trimethyl-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl)benzyl]-3-ethyl urea

There total 7 articles about 1-[4-((5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-17-pentafluoroethyl-5',5',13-trimethyl-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl)benzyl]-3-ethyl urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262049-54-6
(5R,8S,11R,13S,14S,17S)-11-(4-aminomethylphenyl)-17-pentafluoroethyl-5',5',13-trimethyl-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxane]-5,17-diol

: 109-90-0
ethyl isocyanate

: 1262049-53-5
1-[4-((5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-17-pentafluoroethyl-5',5',13-trimethyl-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl)benzyl]-3-ethyl urea

Guidance literature:: In dichloromethane; at 23 ℃; for 1h;

Reference yield:

: (5R,8S,11R,13S,14S,17S)-5',5',13-trimethyl-17-(pentafluoroethyl)-11-(4-vinylphenyl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxane]-5,17(4H)-diol

: 1262049-53-5
1-[4-((5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-17-pentafluoroethyl-5',5',13-trimethyl-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl)benzyl]-3-ethyl urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: osmium(VIII) oxide; triethylamine; sodium periodate; sodium hydrogencarbonate / water; tert-butyl alcohol; tetrahydrofuran / 80 h / 23 °C

2.1: sodium tetrahydroborate; methanol / 2.5 h / 3 °C

3.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 h / 3 - 60 °C

4.1: trimethylphosphane / water; tetrahydrofuran / 4 h / 23 °C

4.2: 16 h / 23 °C

5.1: dichloromethane / 1 h / 23 °C

With methanol; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; diphenyl phosphoryl azide; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trimethylphosphane; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;

Reference yield:

: 1262049-29-5
4-[(5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-5',5',13-trimethyl-17-(pentafluoroethyl)-1,2,4,5,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl]benzaldehyde

: 1262049-53-5
1-[4-((5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-17-pentafluoroethyl-5',5',13-trimethyl-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl)benzyl]-3-ethyl urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate; methanol / 2.5 h / 3 °C

2.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 h / 3 - 60 °C

3.1: trimethylphosphane / water; tetrahydrofuran / 4 h / 23 °C

3.2: 16 h / 23 °C

4.1: dichloromethane / 1 h / 23 °C

With methanol; sodium tetrahydroborate; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; trimethylphosphane; In tetrahydrofuran; dichloromethane; water;