tert-butyl 4-(4-(pyridin-4-yl)phenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(4-(pyridin-4-yl)phenyl)piperazine-1-carboxylate
• CAS No.: 1202880-76-9
• Molecular Formula: C₂₀H₂₅N₃O₂
• Molecular Weight: 339.437
• Mol file: 1202880-76-9.mol

Synonyms:tert-butyl 4-(4-(pyridin-4-yl)phenyl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(4-(pyridin-4-yl)phenyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(4-(pyridin-4-yl)phenyl)piperazine-1-carboxylate

There total 2 articles about tert-butyl 4-(4-(pyridin-4-yl)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-bromopyridine hydrochloride (19524-06-2) + 4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylboronic acid (457613-78-4) → tert-butyl 4-(4-(pyridin-4-yl)phenyl)piperazine-1-carboxylate (1202880-76-9)

Guidance literature:

4-bromopyridine hydrochloride; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 20 ℃; for 0.5h; Inert atmosphere; Reflux;

4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylboronic acid; With sodium carbonate; In 1,2-dimethoxyethane; Reflux; Inert atmosphere;

DOI:10.1021/jm901184n

Reference yield: 43.0%

4-pyridylboronic acid (1692-15-5) + tert-butyl 4-(4-iodophenyl)tetrahydro-1(2H)-pyrazinecarboxylate (151978-66-4) → tert-butyl 4-(4-(pyridin-4-yl)phenyl)piperazine-1-carboxylate (1202880-76-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 90 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.06.025

Reference yield: 91.0%

tert-butyl 4-(4-(pyridin-4-yl)phenyl)piperazine-1-carboxylate (1202880-76-9) → 1-(4-(pyridin-4-yl)phenyl)piperazine (1202880-18-9)

Guidance literature:

tert-butyl 4-(4-(pyridin-4-yl)phenyl)piperazine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate;

DOI:10.1016/j.bmc.2010.06.025

upstream raw materials:

4-bromopyridine hydrochloride

4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylboronic acid

4-pyridylboronic acid

tert-butyl 4-(4-iodophenyl)tetrahydro-1(2H)-pyrazinecarboxylate

Downstream raw materials:

1-(4-(pyridin-4-yl)phenyl)piperazine