C₂₃H₁₈⁽¹⁸⁾FNOS

Base Information

• Chemical Name: C₂₃H₁₈⁽¹⁸⁾FNOS
• CAS No.: 1609535-62-7
• Molecular Formula: C₂₃H₁₈FNOS
• Molecular Weight: 374.468
• Mol file: 1609535-62-7.mol

Synonyms:C₂₃H₁₈⁽¹⁸⁾FNOS

Chemical Property of C₂₃H₁₈⁽¹⁸⁾FNOS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₁₈⁽¹⁸⁾FNOS

There total 6 articles about C₂₃H₁₈⁽¹⁸⁾FNOS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylazulene (769-86-8) → C23H18(18)FNOS (1609535-62-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: trichlorophosphate / 1 h / 0 °C

1.2: 2 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran / 1.25 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

4.1: aluminum (III) chloride / tetrahydrofuran / Reflux

5.1: [18F]fluoride ion, cyclotron produced, NCA; dipotassium hydrogenphosphate; [2.2.2]cryptande / 0.25 h / 110 °C

With triethylsilane; aluminum (III) chloride; dipotassium hydrogenphosphate; n-butyllithium; [2.2.2]cryptande; trifluoroacetic acid; [18F]fluoride ion, cyclotron produced, NCA; trichlorophosphate; In tetrahydrofuran; dichloromethane;

Reference yield:

C23H18BrNOS (247038-50-2) → C23H18(18)FNOS (1609535-62-7)

Guidance literature:

With dipotassium hydrogenphosphate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA; at 110 ℃; for 0.25h;

Reference yield:

(2-methyl-3-((4-methylthiazol-2-yl)methyl)azulen-1-yl)(4 nitrophenyl)methanone (1609535-61-6) → C23H18(18)FNOS (1609535-62-7)

Guidance literature:

With dipotassium hydrogenphosphate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA; In N,N-dimethyl-formamide; at 120 ℃; for 2h; Solvent;

upstream raw materials:

(2-methylazulen-1-yl)(4-methylthiazol-2-yl)methanol

4-methyl-2-((2-methylazulen-1-yl)methyl)thiazole

(2-methyl-3-((4-methylthiazol-2-yl)methyl)azulen-1-yl)(4 nitrophenyl)methanone

C₂₃H₁₈BrNOS