N-(4-hydroxy-4-(2-nitrophenyl)butyl)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamide

Base Information

Chemical Name:N-(4-hydroxy-4-(2-nitrophenyl)butyl)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamide
CAS No.:1621071-25-7
Molecular Formula:C₁₉H₂₀N₆O₇
Molecular Weight:444.404
Hs Code.:

Synonyms:N-(4-hydroxy-4-(2-nitrophenyl)butyl)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamide

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Chemical Property of N-(4-hydroxy-4-(2-nitrophenyl)butyl)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamide

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Technology Process of N-(4-hydroxy-4-(2-nitrophenyl)butyl)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamide

There total 3 articles about N-(4-hydroxy-4-(2-nitrophenyl)butyl)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1621071-19-9
4-amino-1-(2-nitrophenyl)butan-1-ol

: 149079-60-7
3-[N-(7'-nitrobenz-2'-oxa-1',3'-diazol-4'-yl)amino]propanic acid

: 1621071-25-7
N-(4-hydroxy-4-(2-nitrophenyl)butyl)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1039/c4ob00707g

Reference yield:

: 10199-89-0
NBD chloride

: 1621071-25-7
N-(4-hydroxy-4-(2-nitrophenyl)butyl)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / methanol / 3.5 h / 0 - 50 °C / Inert atmosphere

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; acetonitrile;
DOI:10.1039/c4ob00707g

Reference yield:

: 1401067-58-0
2-(4-hydroxy-4-(2-nitrophenyl)butyl)isoindoline-1,3-dione

: 1621071-25-7
N-(4-hydroxy-4-(2-nitrophenyl)butyl)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; acetonitrile;
DOI:10.1039/c4ob00707g