Technology Process of 12-(p-tolyl)-6H-chromeno[3,4-a]indolizin-6-one
There total 5 articles about 12-(p-tolyl)-6H-chromeno[3,4-a]indolizin-6-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate;
In
toluene;
at 20 - 130 ℃;
for 24h;
Inert atmosphere;
DOI:10.1002/chem.201103329
- Guidance literature:
-
With
copper(I) bromide dimethyl sulphide complex;
In
1,2-dichloro-ethane;
at 140 ℃;
Inert atmosphere;
Glovebox;
Schlenk technique;
DOI:10.1039/c5cc07598j
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / water / 1 h / 80 °C
2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C
3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; triethylamine / 4 h / 60 °C / Inert atmosphere; Glovebox; Schlenk technique
4: copper(I) bromide dimethyl sulphide complex / 1,2-dichloro-ethane / 140 °C / Inert atmosphere; Glovebox; Schlenk technique
With
dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(I) bromide dimethyl sulphide complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
tetrahydrofuran; water; 1,2-dichloro-ethane; triethylamine; N,N-dimethyl-formamide;
3: |Sonogashira Cross-Coupling;
DOI:10.1039/c5cc07598j
