Technology Process of [(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methanamine
There total 11 articles about [(2S,3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]methanamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 25h;
Reflux;
-
methanone](/Databaselist/images/loading.webp)
-
1619983-08-2
[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](3,5-dimethoxyphenyl)methanone
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere
1.2: 1.33 h / 0 - 65 °C
2.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C
3.1: sodium hydroxide / tetrahydrofuran; methanol / 3.5 h / 80 °C
4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
4.2: 2 h
5.1: borane-THF / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere
5.2: 2 h / 20 °C / Cooling with ice
6.1: pyridine / 1.5 h / Cooling with ice; Inert atmosphere
7.1: sodium azide / N,N-dimethyl-formamide / 18 h / 60 °C / Inert atmosphere
8.1: water; triphenylphosphine / tetrahydrofuran / 25 h / 20 °C / Reflux
With
pyridine; sodium azide; borane-THF; potassium tert-butylate; water; triphenylphosphine; pyridinium chlorochromate; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
4.1: |Wittig Olefination;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: tin(IV) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
2.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere
2.2: 1.33 h / 0 - 65 °C
3.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C
4.1: sodium hydroxide / tetrahydrofuran; methanol / 3.5 h / 80 °C
5.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere
5.2: 1 h / 20 °C
6.1: hydrogenchloride / tetrahydrofuran / 0.5 h / Reflux
7.1: sodium tetrahydroborate; methanol / 0.58 h / 20 °C / Inert atmosphere; Cooling with ice
8.1: pyridine / 1.5 h / Cooling with ice; Inert atmosphere
9.1: sodium azide / N,N-dimethyl-formamide / 18 h / 60 °C / Inert atmosphere
10.1: water; triphenylphosphine / tetrahydrofuran / 25 h / 20 °C / Reflux
With
pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; sodium azide; borane-THF; potassium tert-butylate; water; tin(IV) chloride; triphenylphosphine; pyridinium chlorochromate; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
