[5-(4-methyl-piperazin-1-yl)-2-nitro-phenyl]-acetic acid ethyl ester

Base Information

• Chemical Name: [5-(4-methyl-piperazin-1-yl)-2-nitro-phenyl]-acetic acid ethyl ester
• CAS No.: 870274-20-7
• Molecular Formula: C₁₅H₂₁N₃O₄
• Molecular Weight: 307.349
• Mol file: 870274-20-7.mol

Synonyms:[5-(4-methyl-piperazin-1-yl)-2-nitro-phenyl]-acetic acid ethyl ester

Chemical Property of [5-(4-methyl-piperazin-1-yl)-2-nitro-phenyl]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5-(4-methyl-piperazin-1-yl)-2-nitro-phenyl]-acetic acid ethyl ester

There total 2 articles about [5-(4-methyl-piperazin-1-yl)-2-nitro-phenyl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) + (2-nitro- 5-bromophenyl)acetic acid ethyl ester (870274-21-8) → [5-(4-methyl-piperazin-1-yl)-2-nitro-phenyl]-acetic acid ethyl ester (870274-20-7)

Guidance literature:

at 65 ℃; for 24h;

Reference yield:

para-nitrophenyl bromide (586-78-7) → [5-(4-methyl-piperazin-1-yl)-2-nitro-phenyl]-acetic acid ethyl ester (870274-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 1.25 h / -40 °C

2: 24 h / 65 °C

With potassium tert-butylate; In tetrahydrofuran;

Reference yield:

[5-(4-methyl-piperazin-1-yl)-2-nitro-phenyl]-acetic acid ethyl ester (870274-20-7) → [2-amino-5-(4-methyl-piperazin-1-yl)-phenyl]-acetic acid ethyl ester (870274-28-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 4h; under 760.051 Torr;

upstream raw materials:

1-methyl-piperazine

(2-nitro- 5-bromophenyl)acetic acid ethyl ester

para-nitrophenyl bromide

Downstream raw materials:

[2-amino-5-(4-methyl-piperazin-1-yl)-phenyl]-acetic acid ethyl ester

2-[5-(4-methyl-piperazin-1-yl)-2-nitro-phenyl]-acetamide

2-[2-amino-5-(4-methyl-piperazin-1-yl)-phenyl]-acetamide

2-[2-acetylamino-5-(4-methyl-piperazin-1-yl)-phenyl]-acetamide